Intertek Scientific & Regulatory Consultancy, Food & Nutrition, Mississauga, ON, Canada.
Intertek Scientific & Regulatory Consultancy, Food & Nutrition, Farnborough, UK.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 May;38(5):701-717. doi: 10.1080/19440049.2020.1859624. Epub 2021 Feb 10.
In 2017, the results of a comprehensive assessment of intake for benzoic acid and its salts from non-alcoholic beverages were published for four regions (Brazil, Canada, Mexico, and the United States [U.S.]). These regions were among those identified as having the most prevalent use of benzoates in beverages globally. The results of the 2017 study did not indicate a safety concern relative to the acceptable daily intake (ADI) established for benzoates (5 mg kg body weight day, as benzoic acid), and supported maintaining the Codex maximum benzoate level in water-based beverages (250 mg kg). Since this time, population-specific food consumption data have been released for public use for Canada, and updated beverage consumption data have become available for the U.S. To ensure estimated intakes remain relevant, these consumption data were incorporated with previously collected brand-specific benzoate use level and market volume data for beverages. Dietary exposure to benzoates from non-alcoholic beverages was assessed using statistical modelling, either probabilistic (non-brand loyal; considering the full distribution of use levels) or deterministic (brand loyal; assuming all regular carbonated soft drinks, the brand loyal beverage type, contain benzoates at the maximum use level, and all other beverage types in which benzoates are used contain benzoates at the market-weighted average use level). In both models, estimated daily intakes at the mean and 95 percentile were below the ADI (≤76% of the ADI) in all Canadian and U.S. population groups with a statistically reliable population size. The findings from updated Canadian and U.S. consumption data continue to support the Codex maximum benzoate level in water-based flavoured drinks at 250 mg kg.
2017 年,对来自非酒精饮料的苯甲酸及其盐的摄入量进行了全面评估,结果发表于四个地区(巴西、加拿大、墨西哥和美国)。这些地区是全球苯甲酸在饮料中使用最普遍的地区之一。2017 年的研究结果表明,与苯甲酸(以苯甲酸计)的可接受日摄入量(ADI)相比,不存在安全问题,并支持维持水基饮料中苯甲酸的最高限量(250mg/kg)。自那时以来,加拿大公布了特定人群的食品消费数据,美国也更新了饮料消费数据。为了确保估计的摄入量仍然相关,这些消费数据与之前收集的特定品牌苯甲酸使用水平和市场份额数据相结合,用于饮料。采用统计建模评估非酒精饮料中苯甲酸的膳食暴露情况,模型包括概率性(非品牌忠诚度;考虑使用水平的完整分布)或确定性(品牌忠诚度;假设所有常规碳酸软饮料,即品牌忠诚度饮料类型,均含有最大使用水平的苯甲酸,以及其他使用苯甲酸的饮料类型均含有市场加权平均使用水平的苯甲酸)。在这两种模型中,在具有统计学可靠性的人群规模下,所有加拿大和美国人群组的平均和 95%百分位的估计日摄入量均低于 ADI(ADI 的≤76%)。更新后的加拿大和美国消费数据的结果继续支持水基调味饮料中 250mg/kg 的最大限量。