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丹麦苯甲酸钠和山梨酸钾的估计摄入量。

Estimated intake of benzoic and sorbic acids in Denmark.

机构信息

Food Chemistry, National Food Institute, DTU, Søborg, Denmark.

出版信息

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Jun;27(6):783-92. doi: 10.1080/19440041003598606.

Abstract

The monitoring of food additives and recent dietary surveys carried out in Denmark have earlier been used to estimate the intake of sweeteners and nitrite in relation to acceptable daily intakes. The ubiquitous use of the preservatives benzoic and sorbic acids raises the question of the magnitude of the intake of these preservatives in relation to acceptable daily intakes. This area is explored in this paper. The content of benzoic and sorbic acids in all food groups, where they are allowed, was monitored in Denmark 17 times between 2001 and 2006 with a total of 1526 samples. Transgressions of maximum limits, illegal use or declaration faults were found in about 3% of samples. From repeated investigations on fat-based foods (salads and dressings), marmalade and stewed fruit, it is concluded that the amounts used in industry have been relatively stable throughout the whole period, although limited data for marmalade show some variation. Most foods in the categories soft drinks, dressings, fat-based salads, pickled herrings, and marmalade contain benzoic and sorbic acid, and sliced bread also contains in some cases sorbic acid. The median daily intake and intake distribution of benzoic and sorbic acids were calculated with data from the Danish National Survey of Dietary Habits and Physical Activity (age from 4 to 75 years) conducted in 2000-2004 with 5785 participants. The median intakes of both benzoic acid and sorbic acid are well below the acceptable daily intakes of 0-5 and 0-25 mg kg(-1) body weight (bw) day(-1) for benzoic and sorbic acid, respectively. However, the 90th percentile based on the average of the samples with a content of benzoic acid is higher than the acceptable daily intake for both men and women, with the highest value of 16 mg kg(-1) bw day(-1) for both boys and girls in the 4-6-year-old age group. Based on the average of all samples, the 95th percentile is over the acceptable daily intake for men up to 34 years and for women up to 24 years, and the 90th percentile for men up to 18 years and for women up to 10 years. Soft drinks, salads and dressings are the main contributors to benzoic acid intake. The sorbic acid intake based on the average of all samples is well below the acceptable daily intake. However, for the intake based on the average of samples with content, the 95th percentile exceeds the acceptable daily intake. This is caused by the dominating contribution to the intake of sorbic acid from sliced bread, but since only seven out of 42 samples have added sorbic acid, the calculation based on the average of samples with content will exaggerate the intake. With a built-in safety factor of 100 in the acceptable daily intakes and judging from the literature, the high intakes of benzoic acid should not cause any concern for ill-effects. However, there must be a reason to reconsider the maximum limits especially for benzoic acid in soft drinks, dressings and salads and for sorbic acid in sliced bread.

摘要

食品添加剂的监测和丹麦最近进行的饮食调查,之前被用来估计甜味剂和亚硝酸盐的摄入量与可接受的日摄入量(ADI)之间的关系。防腐剂苯甲酸和山梨酸的普遍使用引发了一个问题,即这些防腐剂的摄入量与 ADI 相比有多大。本文探讨了这一领域。2001 年至 2006 年期间,丹麦共监测了 1526 个样本,其中 17 次监测了所有允许添加苯甲酸和山梨酸的食品组中的这两种酸的含量。约 3%的样本存在超出最大限量、非法使用或申报错误的情况。从对脂肪类食品(沙拉和调味料)、果酱和炖水果的反复调查中得出结论,工业中使用的量在整个时期相对稳定,尽管果酱的有限数据显示出一些变化。软饮料、调味料、脂肪类沙拉、腌制鲱鱼和果酱等类别的大多数食品都含有苯甲酸和山梨酸,一些切片面包也含有山梨酸。2000-2004 年,丹麦进行了全国饮食和体力活动调查(年龄在 4 至 75 岁之间),利用其中 5785 名参与者的数据计算了苯甲酸和山梨酸的日平均摄入量和摄入量分布。苯甲酸和山梨酸的摄入量中位数均远低于各自的 ADI(0-5 和 0-25mg/kg 体重/天)。然而,基于平均含有苯甲酸的样本的 90 百分位值高于男女的 ADI,4-6 岁年龄组男孩和女孩的最高值分别为 16mg/kg 体重/天。基于所有样本的平均值,95 百分位值超过了 34 岁以下男性和 24 岁以下女性的 ADI,90 百分位值超过了 18 岁以下男性和 10 岁以下女性的 ADI。软饮料、沙拉和调味料是苯甲酸摄入量的主要来源。基于所有样本平均值的山梨酸摄入量远低于 ADI。然而,基于含有山梨酸的样本平均值的摄入量,95 百分位值超过了 ADI。这是由于切片面包对山梨酸摄入量的主导贡献造成的,但由于只有 42 个样本中的 7 个添加了山梨酸,因此基于含有山梨酸的样本平均值的计算会夸大摄入量。由于 ADI 中内置了 100 的安全系数,并且从文献中可以判断,苯甲酸的高摄入量不应该对不良影响造成任何担忧。然而,必须重新考虑特别是软饮料、调味料和沙拉中的苯甲酸和切片面包中的山梨酸的最大限量。

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