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解码抗肿瘤免疫的遗传基础。

Decoding the genetic basis of anti-tumor immunity.

机构信息

Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; BIOPIC, Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing 100871, China.

出版信息

Immunity. 2021 Feb 9;54(2):199-201. doi: 10.1016/j.immuni.2021.01.005.

DOI:10.1016/j.immuni.2021.01.005
PMID:33567259
Abstract

Substantial variations of tumor immune properties exist among cancer patients, but the contributing factors underlying those variations are poorly understood. In this issue of Immunity, Sayaman et al. uncover associations between germline genetic variants and tumor immune properties, revealing candidate causal genes.

摘要

肿瘤患者的肿瘤免疫特性存在很大差异,但这些差异的潜在影响因素尚未被充分了解。在本期《Immunity》杂志中,Sayaman 等人发现了种系遗传变异与肿瘤免疫特性之间的关联,揭示了候选的因果基因。

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Decoding the genetic basis of anti-tumor immunity.解码抗肿瘤免疫的遗传基础。
Immunity. 2021 Feb 9;54(2):199-201. doi: 10.1016/j.immuni.2021.01.005.
2
Germline Analysis from Tumor-Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings.通过肿瘤-胚系测序二元组进行胚系分析以识别具有临床可操作性的次要发现。
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BMC Med Genomics. 2017 May 19;10(1):33. doi: 10.1186/s12920-017-0271-4.
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Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.利用配对正常 DNA 进行靶向肿瘤测序中的种系变异。
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Improved ClickTags enable live-cell barcoding for highly multiplexed single cell sequencing.
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Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance.肿瘤异质性重塑肿瘤微环境以影响药物耐药性。
Int J Biol Sci. 2022 Apr 24;18(7):3019-3033. doi: 10.7150/ijbs.72534. eCollection 2022.