Hang Lixiao, Zhang Ying, Zhang Zheng, Jiang Haiqiang, Xia Lin
Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang, 212001, China.
International Genome Center, Jiangsu University, Zhenjiang, 212013, China.
Cardiovasc Drugs Ther. 2025 Jun;39(3):661-676. doi: 10.1007/s10557-024-07545-5. Epub 2024 Jan 18.
Metabolic disorders of cardiomyocytes play an important role in the progression of various cardiovascular diseases. Metabolic reprogramming can provide ATP to cardiomyocytes and protect them during diseases, but this transformation also leads to adverse consequences such as oxidative stress, mitochondrial dysfunction, and eventually aggravates myocardial injury. Moreover, abnormal accumulation of metabolites induced by metabolic reprogramming of cardiomyocytes alters the cardiac microenvironment and affects the metabolism of immune cells. Immunometabolism, as a research hotspot, is involved in regulating the phenotype and function of immune cells. After myocardial injury, both cardiac resident immune cells and heart-infiltrating immune cells significantly contribute to the inflammation, repair and remodeling of the heart. In addition, metabolites generated by the metabolic reprogramming of immune cells can further affect the microenvironment, thereby affecting the function of cardiomyocytes and other immune cells. Therefore, metabolic reprogramming and abnormal metabolite levels may serve as a bridge between cardiomyocytes and immune cells, leading to the development of cardiovascular diseases. Herein, we summarize the metabolic relationship between cardiomyocytes and immune cells in cardiovascular diseases, and the effect on cardiac injury, which could be therapeutic strategy for cardiovascular diseases, especially in drug research.
心肌细胞的代谢紊乱在各种心血管疾病的进展中起着重要作用。代谢重编程可以为心肌细胞提供ATP并在疾病期间保护它们，但这种转变也会导致氧化应激、线粒体功能障碍等不良后果，并最终加重心肌损伤。此外，心肌细胞代谢重编程诱导的代谢产物异常积累会改变心脏微环境并影响免疫细胞的代谢。免疫代谢作为一个研究热点，参与调节免疫细胞的表型和功能。心肌损伤后，心脏常驻免疫细胞和心脏浸润免疫细胞均对心脏的炎症、修复和重塑有显著作用。此外，免疫细胞代谢重编程产生的代谢产物可进一步影响微环境，从而影响心肌细胞和其他免疫细胞的功能。因此，代谢重编程和异常代谢产物水平可能作为心肌细胞和免疫细胞之间的桥梁，导致心血管疾病的发生。在此，我们总结了心血管疾病中心肌细胞与免疫细胞之间的代谢关系以及对心脏损伤的影响，这可能成为心血管疾病的治疗策略，尤其是在药物研究方面。
