Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Curie-Sklodowska 34 St., 41-819 Zabrze, Poland.
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Curie-Sklodowska 34 St., 41-819 Zabrze, Poland.
Eur J Pharm Biopharm. 2021 Apr;161:29-36. doi: 10.1016/j.ejpb.2021.02.001. Epub 2021 Feb 7.
Glioblastoma multiforme is the most aggressive and lethal form of brain tumour due to the high degree of cancer cells infiltration into surrounding brain tissue. No form of monotherapy can guarantee satisfactory patient outcomes and is only of palliative importance. To find a potential option of glioblastoma treatment the bioresorbable, layer nonwoven mats for controlled temozolomide and nimorazole release were obtained by classical and coaxial electrospinning. Optimization of fibre structure that enables delayed and controlled drug release was performed. The studied bioresorbable polymers were poly(L-lactide-co-ε-caprolactone) and poly(L-lactide-co-glycolide-co-trimethylene carbonate). The physicochemical properties of polymers were determined as well as drug release profiles of nonwoven mats. A combination of coaxial electrospinning and electrospray technique provided three-phased release profiles of temozolomide and nimorazole: the slow release of very low drug doses followed by accelerated release and saturation phase. Results form the basis for further investigation since both studied polymers possess a great potential as nimorazole and temozolomide delivery systems in the form of layered nonwoven implants.
多形性胶质母细胞瘤是最具侵袭性和致命性的脑肿瘤，因为癌细胞高度浸润周围脑组织。没有任何单一疗法可以保证令人满意的患者预后，只能起到姑息治疗的作用。为了寻找胶质母细胞瘤治疗的潜在选择，通过经典同轴静电纺丝法获得了具有生物可降解性、层状无纺垫，用于控制替莫唑胺和尼莫佐胺的释放。优化了纤维结构，实现了药物的延迟和控制释放。研究的生物可降解聚合物为聚（L-丙交酯-co-ε-己内酯）和聚（L-丙交酯-co-乙交酯-co-三亚甲基碳酸酯）。测定了聚合物的物理化学性质以及无纺垫的药物释放曲线。同轴静电纺丝和电喷技术的结合提供了替莫唑胺和尼莫佐胺的三相释放曲线：非常低的药物剂量的缓慢释放，随后是加速释放和饱和阶段。研究结果为进一步的研究奠定了基础，因为两种研究的聚合物都具有作为尼莫佐胺和替莫唑胺输送系统的巨大潜力，以层状无纺植入物的形式存在。
