Center of Polymer and Carbon Materials, Polish Academy of Sciences, Marii Curie-Skłodowskiej 34, 41-819 Zabrze, Poland.
Department of Biopharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, Poland.
Molecules. 2021 Sep 21;26(18):5701. doi: 10.3390/molecules26185701.
Wound healing poses a serious therapeutic problem. Methods which accelerate tissue regeneration and minimize or eliminate complications are constantly being sought. This paper is aimed at evaluation of the potential use of biodegradable polymer nonwovens releasing propolis as wound healing dressings, based on the literature data. Propolis is honeybee product with antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, analgesic, and regenerative properties. Controlled release of this substance throughout the healing should promote healing process, reduce the risk of wound infection, and improve aesthetic effect. The use of biodegradable aliphatic polyesters and polyester carbonates as a propolis carrier eliminates the problem of local drug administration and dressing changes. Well-known degradation processes and kinetics of the active substance release allows the selection of the material composition appropriate to the therapy. The electrospinning method allows the production of nonwovens that protect the wound against mechanical damage. Moreover, this processing technique enables adjusting product properties by modifying the production parameters. It can be concluded that biodegradable polymer dressings, releasing a propolis, may find potential application in the treatment of complicated wounds, as they may increase the effectiveness of treatment, as well as improve the patient's life quality.
伤口愈合是一个严重的治疗问题。人们一直在寻求能够加速组织再生并最小化或消除并发症的方法。本文旨在基于文献数据评估可生物降解聚合物无纺释放物中蜂胶作为伤口愈合敷料的潜在用途。蜂胶是一种具有抗氧化、抗菌、抗真菌、抗癌、抗炎、镇痛和再生特性的蜜蜂产品。在整个愈合过程中控制这种物质的释放应该可以促进愈合过程，降低伤口感染的风险，并改善美观效果。使用可生物降解的脂肪族聚酯和聚酯碳酸酯作为蜂胶载体可以解决局部药物给药和更换敷料的问题。众所周知的活性物质释放的降解过程和动力学允许选择适合治疗的材料组成。静电纺丝方法允许生产保护伤口免受机械损伤的无纺物。此外，这种加工技术可以通过修改生产参数来调整产品性能。可以得出结论，可生物降解聚合物释放物中的蜂胶敷料可能在治疗复杂伤口方面具有潜在的应用，因为它们可以提高治疗效果，改善患者的生活质量。
