Department for Health Evidence, Research Laboratory Molecular Epidemiology, 6500 HB Radboudumc, Nijmegen, The Netherlands.
Department of Medical Microbiology, Radboudumc, 6500 HB Nijmegen, The Netherlands.
Int J Environ Res Public Health. 2021 Feb 8;18(4):1599. doi: 10.3390/ijerph18041599.
During the SARS-CoV-2 pandemic, there was shortage of the standard respiratory protective equipment (RPE). The aim of this study was to develop a procedure to test the performance of alternative RPEs used in the care of COVID-19 patients.
A laboratory-based test was developed to compare RPEs by total inward leakage (TIL). We used a crossflow nebulizer to produce a jet spray of 1-100 µm water droplets with a fluorescent marker. The RPEs were placed on a dummy head and sprayed at distances of 30 and 60 cm. The outcome was determined as the recovery of the fluorescent marker on a membrane filter placed on the mouth of the dummy head.
At 30 cm, a type IIR surgical mask gave a 17.7% lower TIL compared with an FFP2 respirator. At 60 cm, this difference was similar, with a 21.7% lower TIL for the surgical mask compared to the respirator. When adding a face shield, the TIL at 30 cm was further reduced by 9.5% for the respirator and 16.6% in the case of the surgical mask.
A safe, fast and very sensitive test method was developed to assess the effectiveness of RPE by comparison under controlled conditions.
在 SARS-CoV-2 大流行期间,标准呼吸防护设备(RPE)短缺。本研究旨在开发一种测试用于 COVID-19 患者护理的替代 RPE 性能的程序。
开发了一种基于实验室的测试,通过总内漏(TIL)比较 RPE。我们使用横流喷雾器产生带有荧光标记的 1-100 µm 水滴射流。将 RPE 放置在模拟人头模型上,并在 30 和 60 cm 的距离处进行喷雾。结果确定为放置在模拟人头模型口部的膜过滤器上回收的荧光标记。
在 30 cm 处,与 FFP2 呼吸器相比,I 型 II 类外科口罩的 TIL 低 17.7%。在 60 cm 处,这种差异相似,外科口罩的 TIL 比呼吸器低 21.7%。当添加面罩时,呼吸器在 30 cm 处的 TIL 进一步降低了 9.5%,而外科口罩的 TIL 降低了 16.6%。
开发了一种安全、快速且非常敏感的测试方法,通过在受控条件下进行比较来评估 RPE 的有效性。