van Duren B P, Vemer H M, Thomas C M, Verhoef C G, Willemsen W N, Rolland R
Department of Obstetrics and Gynaecology, St Radboud University Hospital, Nijmegen, The Netherlands.
Hum Reprod. 1988 Feb;3(2):219-21. doi: 10.1093/oxfordjournals.humrep.a136680.
Serum human chorionic gonadotrophin (HCG) determinations were performed every other day during the luteal phase of the menstrual cycle of 20 women suffering from unexplained infertility and of 20 women assumed to be fertile. HCG was determined by a specific radioimmunoassay which applied an antiserum directed against the HCG-beta subunit. The group of infertile patients demonstrated detectable serum HCG in only three cases. No clinically confirmed pregnancies were achieved in this group. Eighteen of the 20 women presumed to be fertile showed detectable HCG levels. Five of these achieved ongoing pregnancies, while 13 women revealed increased HCG levels without delayed menstrual periods. The first day of detection of HCG during the luteal phase did not differ between the two groups. In the five women with ongoing pregnancies the time of detection of HCG ranged from day 5 until day 12 after ovulation. It is concluded that the high rate of increased HCG values in the fertile group may represent early conceptual loss, but the apparently disorderly HCG results indicate the need for cautious interpretation of HCG determinations during the luteal phase. Furthermore, early conceptual loss forms no major explanation for unexplained infertility.
在20名不明原因不孕症女性和20名假定可育女性的月经周期黄体期，每隔一天进行血清人绒毛膜促性腺激素（HCG）测定。HCG采用特异性放射免疫分析法测定，该方法使用针对HCG-β亚基的抗血清。不孕患者组仅3例血清HCG可检测到。该组无临床确诊妊娠。20名假定可育的女性中有18名显示HCG水平可检测到。其中5名成功妊娠，13名女性HCG水平升高但月经未延迟。两组黄体期HCG检测的第一天无差异。在5名成功妊娠的女性中，HCG检测时间为排卵后第5天至第12天。结论是，可育组中HCG值升高的高比率可能代表早期妊娠丢失，但明显紊乱的HCG结果表明在黄体期对HCG测定结果的解释需要谨慎。此外，早期妊娠丢失并非不明原因不孕症的主要原因。
