Hayashi M, Kida K, Yamada I, Matsuda H, Sonoda S, Inoue H, Shiga S
Department of Pediatrics, Ehime University School of Medicine, Japan.
J Neuroimmunol. 1988 May;18(2):171-9. doi: 10.1016/0165-5728(88)90064-1.
The relationship between the histocompatibility leukocyte antigen (HLA) phenotypes and the clinical course of myasthenia gravis (MG) was studied in 53 Japanese patients with MG. The frequency of HLA-DRw9 antigen was high in the MG patients who did not need immunosuppressive therapy but only anticholinesterase agents (RR = 4.52; CP less than 0.02), who achieved remission of the disease (RR = 2.98; CP less than 0.05) or who showed a decrease in AChR antibody (Ab) titer (RR = 6.32; CP less than 0.0002), whereas the frequency of HLA-DRw8 antigen was increased in MG patients who underwent immunosuppressive therapy (RR = 4.03; CP less than 0.01), who did not have remission (RR = 4.75; CP less than 0.1) or who showed an increase in AChR Ab titer (RR = 6.48; CP less than 0.01). These data suggest that immunogenetic heterogeneity in MG might be reflected in its clinical course.
对53例日本重症肌无力（MG）患者研究了组织相容性白细胞抗原（HLA）表型与MG临床病程之间的关系。在那些不需要免疫抑制治疗而仅需抗胆碱酯酶药物的MG患者中，HLA - DRw9抗原频率较高（相对危险度RR = 4.52；P值小于0.02），这些患者疾病缓解（RR = 2.98；P值小于0.05）或乙酰胆碱受体（AChR）抗体滴度降低（RR = 6.32；P值小于0.0002）；而在接受免疫抑制治疗的MG患者中，HLA - DRw8抗原频率增加（RR = 4.03；P值小于0.01），这些患者未缓解（RR = 4.75；P值小于0.1）或AChR抗体滴度升高（RR = 6.48；P值小于0.01）。这些数据提示MG的免疫遗传异质性可能反映在其临床病程中。
