PG Department of Chemistry, Vijaya College, Bengaluru 560 004, Karnataka, India.
Salicylates and Chemicals Pvt. Ltd., Hyderabad 500 076, Telangana, India.
Bioorg Med Chem. 2021 Feb 15;32:115973. doi: 10.1016/j.bmc.2020.115973. Epub 2020 Dec 31.
Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a significant assembly motif for the development of new drug entities. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. Therefore, many scientific communities have developed these compounds as intent structure and evaluated their biological activities. The present, review provides brief natural sources of quinoline and including a new extent of quinoline-based marketed drugs. This review also confers information about the biological activities of quinoline derivatives such as antibacterial, antifungal, antimycobacterial, antiviral, anti-protozoal, antimalarial, anticancer, cardiovascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.
在杂环化合物中，喹啉是一种有利的支架，它作为开发新药物实体的重要组装基序出现。喹啉及其具有多种生物活性的衍生物被测试为新药开发的重要化合物类别。因此，许多科学界已经将这些化合物作为目标结构进行开发，并评估了它们的生物活性。本综述提供了简要的天然来源的喹啉，包括基于喹啉的新型上市药物。本综述还介绍了喹啉衍生物的生物活性信息，如抗菌、抗真菌、抗分枝杆菌、抗病毒、抗原生动物、抗疟、抗癌、心血管、中枢神经系统作用、抗氧化、抗惊厥、镇痛、抗炎、驱虫和杂项活性。
