Department of Oral and Maxillofacial Surgery, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Dentistry & Craniomaxillofacial Surgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India, Phone: +91 9956403867, e-mail:
J Contemp Dent Pract. 2020 Sep 1;21(9):986-991.
The aim of the study was to compare the healing and osseous regeneration of mandibular third molar extraction sockets with and without platelet-rich plasma (PRP) with the evaluation of clinical objectives such as pain, swelling, trismus, soft tissue healing, pocket depth distal to second molar and radiological evaluation of the bony density in the postextracted third molar socket.
In this prospective study, 100 patients were selected by the random sampling method from the outpatient department of oral and maxillofacial surgery in the year 2016-2017. Patients were equally allocated into intervention (transalveolar extraction followed by PRP placement) and nonintervention (transalveolar extraction without PRP placement) group as group I and group II, respectively, and evaluation parameters were considered accordingly. The statistical analysis was done using SPSS (Statistical Package for Social Sciences) Version 15.0 (IBM, USA) statistical analysis software.
The pain score of patients of group I (non-PRP) was found to be higher as compared to group II (with PRP). Mean trismus of patients of group II was found to be higher than that of group I at postoperative day 7, but this difference was not found to be statistically significant. Swelling at T-Sn (Tragus-Subnasale) and T-Pog (Tragus-Pogonion) was higher among patients of group I as compared to group II. Healing in group II was two to three times faster than group I. Healing among patients of group I and group II was found to be statistically significant. The mean pocket depth of patients of group I was found to be significantly higher than that of group II at follow-up of 1 and 2 months. The bone density of patients of group II was found to be significantly higher than that of group I at 3 months and 6 months follow-up.
The procedure of PRP preparation is simple and cost-effective, and can be prepared at the point of care. It had a significant impact on the postoperative healing of the third molar socket.
The use of PRP application increases the bone density, healing process, and improvement in the pain and swelling, and there was a definite reduction in trismus and periodontal probing depth after the impacted mandibular wisdom teeth extraction.
本研究旨在比较富含血小板血浆（PRP）与不使用 PRP 对下颌第三磨牙拔牙窝的愈合和骨再生的影响，并通过疼痛、肿胀、张口受限、软组织愈合、第二磨牙远中牙周袋深度和拔牙后第三磨牙牙槽窝骨密度的影像学评估等临床指标进行评估。
本前瞻性研究于 2016 年至 2017 年采用随机抽样法从口腔颌面外科门诊选择了 100 例患者。将患者平均分配至干预组（经牙槽突切开后放置 PRP）和非干预组（经牙槽突切开不放置 PRP），分别为组 I 和组 II，并相应考虑评估参数。使用 SPSS（社会科学统计软件包）版本 15.0（IBM，美国）统计分析软件进行统计分析。
组 I（非 PRP）患者的疼痛评分高于组 II（使用 PRP）患者。组 II 患者术后第 7 天的张口受限均值高于组 I，但差异无统计学意义。组 I 患者的 T-Sn（耳屏-鼻下点）和 T-Pog（耳屏-颏点）肿胀高于组 II。组 II 的愈合速度比组 I 快 2 到 3 倍。组 I 和组 II 的患者愈合情况有统计学意义。组 I 患者的平均牙周袋深度在 1 个月和 2 个月的随访中明显高于组 II。组 II 患者在 3 个月和 6 个月随访时的骨密度明显高于组 I。
PRP 制备过程简单且经济有效，可在护理点制备。它对第三磨牙拔牙窝的术后愈合有显著影响。
PRP 应用可增加骨密度、愈合过程，并改善疼痛和肿胀，同时在拔除下颌阻生智齿后可明显减轻张口受限和牙周袋探诊深度。
