Bhatt A, Khan S, Pandya K P, Sabri M I
Industrial Toxicology Research Centre, Lucknow, India.
J Appl Toxicol. 1988 Feb;8(1):53-7. doi: 10.1002/jat.2550080109.
The effects of neurotoxic solvents, i.e. 2,5-hexanedione (2,5-HD), 2,5-hexanediol (2,5-HDiol) and the non-neurotoxic solvent, 2,4-hexanedione (2,4-HD) (500 mg/kg body wt./day, i.p.), have been studied on the lipid composition of brain and sciatic nerves in weanling rats. Five-day-old rats were administered a solvent daily for 21 days. Clinical signs of peripheral neuropathy appeared in 2,5-HD and 2,5-HDiol treated groups. Absolute weights of brain, spleen, thymus significantly decreased with 2,5-HD. Cholesterol content in whole brain homogenates and myelin was significantly reduced with 2,5-HD and 2,5-HDiol treatment. There was also a significant reduction in ubiquinone content of brain with 2,5-HD and 2,5-HDiol treatment. On exposure to neurotoxic chemicals to weanling rats, significant alteration in lipid profile was observed in the brain, which may be one of the key factors in the development of neuropathy.
研究了神经毒性溶剂，即2,5 - 己二酮（2,5 - HD）、2,5 - 己二醇（2,5 - HDiol）以及非神经毒性溶剂2,4 - 己二酮（2,4 - HD）（腹腔注射，500毫克/千克体重/天）对断奶大鼠脑和坐骨神经脂质组成的影响。5日龄大鼠每天给予一种溶剂，持续21天。在2,5 - HD和2,5 - HDiol处理组中出现了周围神经病变的临床症状。2,5 - HD使脑、脾、胸腺的绝对重量显著降低。2,5 - HD和2,5 - HDiol处理使全脑匀浆和髓磷脂中的胆固醇含量显著降低。2,5 - HD和2,5 - HDiol处理还使脑中泛醌含量显著降低。断奶大鼠接触神经毒性化学物质后，脑中脂质谱发生了显著改变，这可能是神经病变发展的关键因素之一。
