Prantera C, Davoli M, Lorenzetti R, Pallone F, Marcheggiano A, Iannoni C, Mariotti S
Divisione di Gastroenterologia, Ospedale Nuovo Regina Margherita, Rome, Italy.
J Clin Gastroenterol. 1988 Feb;10(1):41-5. doi: 10.1097/00004836-198802000-00010.
We estimated the extent of the inflammatory mucosal lesion by colonoscopy and biopsy in 60 patients with their first attack of ulcerative colitis. Proctitis was found in 12, proctosigmoiditis in 19, left-sided colitis in 10, and extensive colitis in 19. Fourteen clinical variables and laboratory measurements (bowel frequency, stool consistency, rectal bleeding, fecal mucus/pus, temperature, pulse rate, white blood cell count, hematocrit, sedimentation rate, serum iron, serum albumin, serum alpha 2-globulin, serum C-reactive protein, and seromucoids) were determined. All the variables except rectal bleeding and hematocrit were correlated (p less than 0.001) with the extent of colitis. On stepwise discriminant analysis, only C-reactive protein distinguished proctosigmoiditis from more improved the discrimination. Cross-validation by the "jack-knife method" showed that 86.7% of patients were correctly classified, the errors consisting in underestimation of disease in 8/29 patients with extensive colitis.
我们通过结肠镜检查和活检评估了60例初发溃疡性结肠炎患者的炎性黏膜病变程度。发现直肠炎12例，直肠乙状结肠炎19例，左侧结肠炎10例，广泛性结肠炎19例。测定了14项临床变量和实验室指标（排便次数、大便性状、直肠出血、粪便黏液/脓液、体温、脉搏率、白细胞计数、血细胞比容、血沉、血清铁、血清白蛋白、血清α2球蛋白、血清C反应蛋白和血清类黏蛋白）。除直肠出血和血细胞比容外，所有变量均与结肠炎程度相关（p<0.001）。逐步判别分析显示，只有C反应蛋白能区分直肠乙状结肠炎与其他类型，且改善了判别效果。通过“留一法”交叉验证表明，86.7%的患者分类正确，错误在于对8/29例广泛性结肠炎患者的病情低估。
