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前交叉韧带重建后股外侧肌卫星细胞凋亡增加。

Increased satellite cell apoptosis in vastus lateralis muscle after anterior cruciate ligament reconstruction.

机构信息

Sports Medicine, Medical Clinic, University Hospital Heidelberg, Heidelberg, Germany.

出版信息

J Rehabil Med. 2021 Feb 17;53(2):jrm00153. doi: 10.2340/16501977-2794.

DOI:10.2340/16501977-2794
PMID:33569607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8814877/
Abstract

OBJECTIVE

Recovery of the quadriceps femoris muscle after anterior ligament reconstruction is im-paired. The aim of this study was to investigate satellite cell content and function of the vastus lateralis muscle after anterior ligament reconstruction.

METHODS

Biopsies were obtained from the vastus lateralis muscle of 16 recreational athletes immediately before and again 12 weeks after anterior ligament reconstruction. Total satellite cell number (Pax7+), activated (Pax7+/MyoD+), differentiating (Pax7-/MyoD+), and apoptotic (Pax7+/TUNEL+) satellite cells, myofibers expressing myosin heavy chain (MHC) I and II, and neonatal MHC (MHCneo) were determined immunohistochemically.

RESULTS

After anterior ligament reconstruction, the number of apoptotic satellite cells was significantly (p = 0.019) increased, concomitant with a significant (p < 0.001) decrease in total satellite cell number, with no change in activated and differentiating satellite cell number. MHCneo+ myofibers tended towards an increase.

CONCLUSION

Satellite cell apoptosis and the reduction in the satellite cell pool might provide an explanation for prolonged quadriceps muscle atrophy after anterior ligament reconstruction.

摘要

目的

前交叉韧带重建后股四头肌的恢复受到损害。本研究旨在探讨前交叉韧带重建后股外侧肌卫星细胞的含量和功能。

方法

16 名业余运动员在接受前交叉韧带重建术前和术后 12 周时，从股外侧肌获取活检。用免疫组织化学法测定总卫星细胞数（Pax7+）、激活（Pax7+/MyoD+）、分化（Pax7-/MyoD+）和凋亡（Pax7+/TUNEL+）卫星细胞、表达肌球蛋白重链（MHC）I 和 II 的肌纤维以及新生 MHC（MHCneo）。

结果

前交叉韧带重建后，凋亡卫星细胞数量显著增加（p=0.019），同时总卫星细胞数量显著减少（p<0.001），而激活和分化的卫星细胞数量没有变化。MHCneo+肌纤维有增加的趋势。

结论

卫星细胞凋亡和卫星细胞池的减少可能解释了前交叉韧带重建后股四头肌萎缩的持续时间延长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/ba0c59a8e8f8/JRM-53-2-2754-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/f899af34ef71/JRM-53-2-2754-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/35a5ed065d47/JRM-53-2-2754-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/d6d2cefd3f23/JRM-53-2-2754-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/0d065a6a7e61/JRM-53-2-2754-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/ba0c59a8e8f8/JRM-53-2-2754-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/f899af34ef71/JRM-53-2-2754-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/35a5ed065d47/JRM-53-2-2754-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/d6d2cefd3f23/JRM-53-2-2754-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/0d065a6a7e61/JRM-53-2-2754-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efad/8814877/ba0c59a8e8f8/JRM-53-2-2754-g005.jpg

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