t(11;22)导致 3' CCND1 截断，从而使 blastoid 套细胞淋巴瘤的 SP4 CCND1 免疫组化呈阴性。
Truncation of 3' CCND1 by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma.
机构信息
Tenri Institute of Medical Research, Tenri, Japan.
Department of Hematology and.
出版信息
Blood Adv. 2021 Jan 12;5(1):61-65. doi: 10.1182/bloodadvances.2020003417.
Abstract
t(11;22)(q13;q11)/-IGL resulted in truncation of the 3′ coding sequences in a case of blastoid variant mantle cell lymphoma. The translocation generated CCND1 with a C-terminal alteration, leading to negative CCND1 immunohistochemistry by SP4 monoclonal antibody.
摘要
t(11;22)(q13;q11)/-IGL 导致一例 blastoid 变体套细胞淋巴瘤中 3′编码序列的截断。易位导致 CCND1 发生 C 末端改变，从而使 SP4 单克隆抗体的 CCND1 免疫组化呈阴性。
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