Lohmander L S, Wingstrand H, Heinegård D
Department of Orthopaedic Surgery, University Hospital in Lund, Sweden.
J Orthop Res. 1988;6(3):420-4. doi: 10.1002/jor.1100060313.
The levels of proteoglycan antigen were measured in joint aspirates from the hip of children with transient synovitis, septic arthritis, Legg-Calvé-Perthes' disease and congenital and traumatic dislocation. Significantly increased levels were found in children with transient synovitis and septic arthritis as compared with other conditions. We propose that the proteoglycan antigens in the joint fluid were released from the articular cartilage in a partially degraded form as a result of an increased rate of proteolytic degradation. In transient synovitis, the source of proteolytic activity may be chondrocytes activated by factors released by synovial cells. The release of joint proteoglycan may cause a temporary increase in deformability of the hip cartilage of the child that could be an important pathogenetic mechanism in some of the sequelae of these diseases.
对患有短暂性滑膜炎、化脓性关节炎、Legg-Calvé-Perthes病以及先天性和创伤性脱位的儿童髋关节关节抽吸物中的蛋白聚糖抗原水平进行了测量。与其他病症相比，短暂性滑膜炎和化脓性关节炎患儿的蛋白聚糖抗原水平显著升高。我们认为，关节液中的蛋白聚糖抗原是以部分降解的形式从关节软骨中释放出来的，这是蛋白水解降解速率增加的结果。在短暂性滑膜炎中，蛋白水解活性的来源可能是被滑膜细胞释放的因子激活的软骨细胞。关节蛋白聚糖的释放可能会导致儿童髋关节软骨的可变形性暂时增加，这可能是这些疾病某些后遗症的重要发病机制。
