关于Legg-Calvé-Perthes病生物力学的新见解：骨骺骨骼未成熟在血管阻塞中的作用。
New insights into the biomechanics of Legg-Calvé-Perthes' disease: The Role of Epiphyseal Skeletal Immaturity in Vascular Obstruction.
作者信息
Pinheiro M, Dobson C A, Perry D, Fagan M J
机构信息
School of Engineering and Computer Science, University of Hull, Cottingham Road, Kingstonupon-Hull HU6 7RX, UK
School of Engineering and Computer Science, University of Hull, Cottingham Road, Kingstonupon-Hull HU6 7RX, UK.
出版信息
Bone Joint Res. 2018 Feb;7(2):148-156. doi: 10.1302/2046-3758.72.BJR-2017-0191.R1.
OBJECTIVES
Legg-Calvé-Perthes' disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed that interruption of the blood supply to the developing epiphysis is an important factor in the development of the condition.
METHODS
Finite element analysis modelling of the blood supply to the juvenile epiphysis was investigated to understand under which circumstances the blood vessels supplying the femoral epiphysis could become obstructed. The identification of these conditions is likely to be important in understanding the biomechanics of LCP.
RESULTS
The results support the hypothesis that vascular obstruction to the epiphysis may arise when there is delayed ossification and when articular cartilage has reduced stiffness under compression.
CONCLUSION
The findings support the theory of vascular occlusion as being important in the pathophysiology of Perthes disease.: M. Pinheiro, C. A. Dobson, D. Perry, M. J. Fagan. New insights into the biomechanics of Legg-Calvé-Perthes' disease: The Role of Epiphyseal Skeletal Immaturity in Vascular Obstruction. 2018;7:148-156. DOI: 10.1302/2046-3758.72.BJR-2017-0191.R1.
目的
莱-卡-佩病（LCP）是一种股骨头特发性骨坏死，在4至8岁儿童中最为常见。导致LCP发病的因素仍不清楚；然而，人们认为发育中的骨骺血液供应中断是该病发展的一个重要因素。
方法
对青少年骨骺血液供应进行有限元分析建模，以了解在何种情况下供应股骨骨骺的血管可能受阻。确定这些情况可能对理解LCP的生物力学很重要。
结果
结果支持这样的假设，即当骨化延迟且关节软骨在压缩下刚度降低时，骨骺的血管可能会阻塞。
结论
这些发现支持血管阻塞理论在佩吉特病病理生理学中很重要的观点。：M.皮涅罗、C.A.多布森、D.佩里、M.J.费根。莱-卡-佩病生物力学的新见解：骨骺骨骼不成熟在血管阻塞中的作用。2018年；7：148 - 156。DOI：10.1302/2046 - 3758.72.BJR - 2017 - 0191.R1。
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