Department of Physics, School of Science, Tianjin Chengjian University, Tianjin 300384, China.
Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, Institute of Advanced Materials Physics, School of Science, Tianjin University, Tianjin 300350, China.
Bioconjug Chem. 2021 Mar 17;32(3):411-429. doi: 10.1021/acs.bioconjchem.0c00648. Epub 2021 Feb 11.
Radiotherapy has been widely used in clinical cancer treatment. However, the ionizing radiation required to kill the tumor will inevitably cause damage to the surrounding normal tissues. To minimize the radiation damage and side effects, small molecular radioprotective agents have been used as clinical adjuvants for radiation protection of healthy tissues. However, the shortcomings of small molecules such as short circulation time and rapid kidney clearance from the body greatly hinder their biomedical applications. In recent years, nanozymes have attracted much attention because of their potential to treat a variety of diseases. Nanozymes exhibit catalytic properties and antioxidant capabilities to provide a potential solution for the development of high-efficiency radioprotective agents in radiotherapy and nuclear radiation accidents. Therefore, in this review, we systematically summarize the catalytic nanozymes used for radiation protection of healthy tissues and discuss the challenges and future prospects of nanomaterials in the field of radiation protection.
放射治疗已广泛应用于临床癌症治疗。然而，杀死肿瘤所需的电离辐射不可避免地会对周围正常组织造成损害。为了将辐射损伤和副作用降到最低，小分子放射防护剂已被用作健康组织辐射防护的临床佐剂。然而，小分子的缺点，如循环时间短和从体内快速清除肾脏，极大地阻碍了它们在生物医学中的应用。近年来，纳米酶因其治疗多种疾病的潜力而引起了广泛关注。纳米酶具有催化特性和抗氧化能力，为开发放射治疗和核辐射事故中高效的放射防护剂提供了一种潜在的解决方案。因此，在本综述中，我们系统地总结了用于健康组织放射防护的催化纳米酶，并讨论了纳米材料在放射防护领域的挑战和未来前景。
