Core Facilities of West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
J Nanobiotechnology. 2022 Feb 22;20(1):92. doi: 10.1186/s12951-022-01295-y.
Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed with the catalytic reactions of natural enzymes. In the field of biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic activities of nanozymes can be regulated by multiple factors, such as the chemical state of metal ion, pH, hydrogen peroxide (HO), and glutathione (GSH) level, presenting great promise for biomedical applications. Over the past decade, multi-functional nanozymes have been developed for various biomedical applications. To promote the understandings of nanozymes and the development of novel and multifunctional nanozymes, we herein provide a comprehensive review of the nanozymes and their applications in the biomedical field. Nanozymes with versatile enzyme-like properties are briefly overviewed, and their mechanism and application are discussed to provide understandings for future research. Finally, underlying challenges and prospects of nanozymes in the biomedical frontier are discussed in this review.
纳米酶是一系列具有模拟酶活性的纳米材料，能够进行天然酶的催化反应。在生物医学领域，由于纳米酶具有高稳定性和低成本的特点，因此受到了极大的关注。纳米酶的模拟酶活性可以通过多种因素进行调节，例如金属离子的化学状态、pH 值、过氧化氢 (HO) 和谷胱甘肽 (GSH) 水平等，这为其在生物医学中的应用提供了广阔的前景。在过去的十年中，已经开发出了多种用于各种生物医学应用的多功能纳米酶。为了促进对纳米酶的理解和新型多功能纳米酶的发展，我们在此全面综述了纳米酶及其在生物医学领域的应用。本文简要概述了具有多种酶样特性的纳米酶，并讨论了它们的作用机制和应用，为未来的研究提供了一定的理解。最后，本文还讨论了纳米酶在生物医学前沿领域所面临的挑战和前景。
