Section of Biomagnetism, Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Chair of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Physiology/Physics, University of Applied Sciences and Medical University, Medical School Hamburg, Hamburg, Germany.
Clin Neurophysiol. 2021 Mar;132(3):770-781. doi: 10.1016/j.clinph.2020.11.042. Epub 2021 Jan 19.
Nociceptive activity in some brain areas has concordantly been reported in EEG source models, such as the anterior/mid-cingulate cortex and the parasylvian area. Whereas the posterior insula has been constantly reported to be active in intracortical and fMRI studies, non-invasive EEG and MEG recordings mostly failed to detect activity in this region. This study aimed to determine an appropriate inverse modeling approach in EEG recordings to model posterior insular activity, assuming the late LEP (laser evoked potential) time window to yield a better separation from other ongoing cortical activity.
In 12 healthy volunteers, nociceptive stimuli of three intensities were applied. LEP were recorded using 32-channel EEG recordings. Source analysis was performed in specific time windows defined in the grand-average dataset. Two distinct dipole-pairs located close to the operculo-insular area were compared.
Our results show that posterior insular activity yields a substantial contribution to the latest part (positive component) of the LEP.
Even though the initial insular activity onset is in the early LEP time window,modelingthe insular activity in the late LEP time window might result in better separation from other ongoing cortical activity.
Modeling the late LEP activity might enable to distinguish posterior insular activity.
在 EEG 源模型中，如前/中扣带皮层和旁矢状区，已经一致报道了一些脑区的伤害性活动。虽然在皮层内和 fMRI 研究中经常报道后岛活动，但非侵入性 EEG 和 MEG 记录大多未能检测到该区域的活动。本研究旨在确定 EEG 记录中合适的逆模型方法，以模拟后岛活动，假设晚期 LEP（激光诱发电位）时间窗口能够更好地区分其他正在进行的皮层活动。
在 12 名健康志愿者中，应用了三种强度的伤害性刺激。使用 32 通道 EEG 记录记录 LEP。在平均数据集定义的特定时间窗口中进行源分析。比较了两个位于近岛叶区域的不同偶极子对。
我们的结果表明，后岛活动对 LEP 的最新部分（正成分）有很大的贡献。
尽管初始岛叶活动的起始时间在 LEP 的早期时间窗口，但在 LEP 的晚期时间窗口中模拟岛叶活动可能会更好地与其他正在进行的皮层活动分离。
模拟晚期 LEP 活动可能能够区分后岛叶活动。
