Cash E, Chamorro M, Brahic M
Département de Virologie, Institut Pasteur, Paris, France.
J Virol. 1988 May;62(5):1824-6. doi: 10.1128/JVI.62.5.1824-1826.1988.
Theiler's virus, a murine picornavirus, causes a chronic neurological disease characterized by primary demyelination in SJL/J mice. The lesions are very reminiscent of those of multiple sclerosis. Theiler's virus persists in oligodendrocytes and to a lesser extent in astrocytes and macrophages throughout the disease. Viral RNA and capsid protein syntheses are minimal in these cells. This restriction could play a central role in the mechanism of virus persistence. By quantitating plus- and minus-strand RNAs in infected central nervous system cells, we showed that RNA replication was blocked at the level of minus-strand RNA synthesis.
泰勒氏病毒是一种鼠源微小核糖核酸病毒，可在SJL/J小鼠中引发以原发性脱髓鞘为特征的慢性神经疾病。这些病变与多发性硬化症的病变极为相似。在整个疾病过程中，泰勒氏病毒持续存在于少突胶质细胞中，在星形胶质细胞和巨噬细胞中的存在程度较低。这些细胞中病毒RNA和衣壳蛋白的合成极少。这种限制可能在病毒持续存在的机制中起核心作用。通过对受感染中枢神经系统细胞中的正链和负链RNA进行定量分析，我们发现RNA复制在负链RNA合成水平受阻。
