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[具体物质名称]对乙醇诱导的胃溃疡的抗炎作用：用于确定作用机制和活性成分的分析、体外及体内研究

Anti-Inflammatory Effect of on Ethanol-Induced Gastric Ulcer: Analytical, In Vitro and In Vivo Studies for the Identification of Action Mechanism and Active Compounds.

作者信息

Shin Myoung-Sook, Lee Jaemin, Lee Jin Woo, Park Se Hoon, Lee Il Kyun, Choi Jung A, Lee Jung Suk, Kang Ki Sung

机构信息

Korean Medicine, Gachon University, Seongnam-si, Gyeonggi-do 13120, Korea.

Research & Development Center, Richwood Pharmaceuticals, 1, Gwanak-gu, Seoul 08826, Korea.

出版信息

Plants (Basel). 2021 Feb 9;10(2):332. doi: 10.3390/plants10020332.

DOI:10.3390/plants10020332
PMID:33572173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7914715/
Abstract

is widely used as traditional medicine in East Asia. However, its effects against inflammation and gastric ulcers have not been reported yet. We analyzed anti-inflammatory activity and its molecular mechanisms of using RAW264.7 cells line, then evaluated the curative efficacy in rats with acute gastric ulcers. Nitric oxide and IL-6 production was measured using Griess reagent and an ELISA kit. Inducible nitric oxide synthase (iNOS), interleukin (IL)-6, and mucin (MUC)1, MUC5AC, and MUC6 mRNA were determined by SYBR Green or Taqman qRT-PCR methods. The phosphorylation of ERK, JNK, p38, and c-Jun protein were detected by western blotting. RW0117 inhibited LPS-induced NO and IL-6 production. The mRNA levels of iNOS and IL-6 were strongly suppressed. The phosphorylation of ERK, JNK, and c-Jun decreased by treatment with RW0117. Oral administration of RW0117 recovered the amount of mucin mRNA and protein level that was decreased due to gastric ulcers by HCl-EtOH. exhibited strong anti-inflammatory effects and contributed to the modulation of HCl-EtOH-induced gastric ulcer in rats.

摘要

在东亚地区被广泛用作传统药物。然而，其抗炎和抗胃溃疡作用尚未见报道。我们使用RAW264.7细胞系分析了[具体物质]的抗炎活性及其分子机制，然后评估了其对大鼠急性胃溃疡的治疗效果。使用格里斯试剂和ELISA试剂盒检测一氧化氮和IL-6的产生。通过SYBR Green或Taqman qRT-PCR方法测定诱导型一氧化氮合酶（iNOS）、白细胞介素（IL）-6以及粘蛋白（MUC）1、MUC5AC和MUC6的mRNA水平。通过蛋白质印迹法检测ERK、JNK、p38和c-Jun蛋白的磷酸化。RW0117抑制LPS诱导的NO和IL-6产生。iNOS和IL-6的mRNA水平被强烈抑制。用RW0117处理后，ERK、JNK和c-Jun的磷酸化降低。口服RW0117可恢复因HCl-EtOH诱导的胃溃疡而降低的粘蛋白mRNA量和蛋白质水平。[具体物质]表现出强大的抗炎作用，并有助于调节大鼠中HCl-EtOH诱导的胃溃疡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/dea61a93c937/plants-10-00332-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/0c31fb3f4df7/plants-10-00332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/cde1feecdc1c/plants-10-00332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/ae65f546f9df/plants-10-00332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/838409c33df1/plants-10-00332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/de32209a6a8d/plants-10-00332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/96758a35d635/plants-10-00332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/e1dd820be27b/plants-10-00332-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/dea61a93c937/plants-10-00332-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/0c31fb3f4df7/plants-10-00332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/cde1feecdc1c/plants-10-00332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/ae65f546f9df/plants-10-00332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/838409c33df1/plants-10-00332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/de32209a6a8d/plants-10-00332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/96758a35d635/plants-10-00332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/e1dd820be27b/plants-10-00332-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/458c/7914715/dea61a93c937/plants-10-00332-g008.jpg

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