Laboratory of Molecular Oncology and Precision Medicine, Biogem Scarl, Institute of Genetic Research, 83031 Ariano Irpino, Italy.
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Int J Mol Sci. 2021 Feb 9;22(4):1741. doi: 10.3390/ijms22041741.
Long noncoding RNAs (lncRNAs) represent key regulators of gene transcription during the inflammatory response. Recent findings showed lncRNAs to be dysregulated in human diseases, such as inflammatory bowel disease, diabetes, allergies, asthma, and cancer. These noncoding RNAs are crucial for immune mechanism, as they are involved in differentiation, cell migration and in the production of inflammatory mediators through regulating protein-protein interactions or their ability to assemble with RNA and DNA. The last interaction can occur in cis or trans and is responsible for all the possible lncRNAs biological effects. Our proposal is to provide an overview on lncRNAs roles and functions related to immunity and immune mediated diseases, since these elucidations could be beneficial to untangle the complex bond between them.
长链非编码 RNA（lncRNA）在炎症反应过程中是基因转录的关键调节因子。最近的研究结果表明，lncRNA 在人类疾病中失调，如炎症性肠病、糖尿病、过敏、哮喘和癌症。这些非编码 RNA 对免疫机制至关重要，因为它们参与了分化、细胞迁移以及通过调节蛋白质-蛋白质相互作用或与其结合的 RNA 和 DNA 的能力来产生炎症介质。最后一种相互作用可以在顺式或反式发生，负责所有可能的 lncRNA 生物学效应。我们的建议是提供有关 lncRNA 与免疫和免疫介导的疾病相关的作用和功能的概述，因为这些阐明可能有助于理清它们之间复杂的关系。
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