Coletta Riccardo, Mussi Elisa, Uccheddu Francesca, Volpe Yary, Morabito Antonino
Department of Pediatric Surgery, Meyer Children's Hospital, Viale Pieraccini 24, 50141 Florence, Italy.
Department of Industrial Engineering, University of Florence, Via Santa Marta 3, 50139 Florence, Italy.
Bioengineering (Basel). 2021 Jan 31;8(2):20. doi: 10.3390/bioengineering8020020.
Short bowel syndrome is a pathological condition resulting from extensive resection of the intestine, generally performed due to congenital abnormalities, Crohn's disease, mesenteric ischemia, or neoplasms. The main consequence of this syndrome is a reduction of intestinal absorption, which causes malnutrition and dehydration. In the most severe cases, specific and complex surgical procedures are requested to manage the syndrome. Such procedures consist of the intestinal lengthening, with lead to an increase of absorptive mucosal surface and intestinal transit time and an overall enhancement of intestinal absorption. One of the most promising surgical procedures is spiral intestinal lengthening and tailoring, which consists of a spiral incision of the intestinal wall and in the elongation longitudinally of the intestine by sliding one flap over the other. The final intestinal lengthening is strictly dependent on a series of parameters, some of which are defined by the surgeon. The present paper proposes a mathematical model, based on patient specific anatomical data, which aims to help the surgeon in defining the optimal parameters for the intervention and in foreseeing its outcomes from the preoperative planning phase. Such a tool can assist the physician in the surgery room by improving the procedure and reducing surgical times.
短肠综合征是一种因广泛切除肠道而导致的病理状况，通常是由于先天性异常、克罗恩病、肠系膜缺血或肿瘤而进行肠道切除。该综合征的主要后果是肠道吸收减少，进而导致营养不良和脱水。在最严重的情况下，需要采用特定且复杂的外科手术来治疗该综合征。此类手术包括肠道延长术，这会增加吸收性黏膜表面积和肠道传输时间，并全面提高肠道吸收能力。最具前景的外科手术之一是螺旋式肠道延长与剪裁术，该手术包括在肠壁上做螺旋形切口，并通过将一个肠瓣滑过另一个肠瓣使肠道纵向延长。最终的肠道延长严格取决于一系列参数，其中一些参数由外科医生确定。本文提出了一个基于患者特定解剖数据的数学模型，旨在帮助外科医生确定手术的最佳参数，并在术前规划阶段预测手术结果。这样一种工具可以通过改进手术过程和缩短手术时间来协助手术室中的医生。
