Laboratory of Clinical Oncology, National Cancer Institute, 1 Santariskiu Str., LT-08406 Vilnius, Lithuania.
Clinic of Internal Medicine, Faculty of Medicine, Family Medicine and Oncology Institute of Clinical Medicine, Vilnius University, M. K. Čiurlionio Str. 21/27, LT-03101 Vilnius, Lithuania.
Int J Environ Res Public Health. 2021 Jan 29;18(3):1191. doi: 10.3390/ijerph18031191.
: Recently, reports have suggested that rates of liver cancer have increased during the last decades in developed countries; increasing hepatocellular carcinoma and cholangiocarcinoma rates were reported. The aim of this study was to examine time trends in incidence and mortality rates of liver cancer for the period of 1998-2015 in Lithuania by sex, age, and histology. : We examined the incidence of liver cancer from 1998 to 2015 using data from the Lithuanian Cancer Registry. Age-standardized incidence rates were calculated by sex, age, and histology. Trends were analyzed using the Joinpoint Regression Program to estimate the annual percent change. : A total of 3086 primary liver cancer cases were diagnosed, and 2923 patients died from liver cancer. The total number of liver cancer cases changed from 132 in 1998 to 239 in 2015. Liver cancer incidence rates changed during the study period from 5.02/100,000 in 1998 to 10.54/100,000 in 2015 in men and from 2.43/100,000 in 1998 to 6.25/100,000 in 2015 in women. Annual percentage changes (APCs) in the age-standardized rates over this period were 4.5% for incidence and 3.6% for mortality. Hepatocellular cancer incidence rates were stable from 1998 to 2005 (APC -5.9, = 0.1) and later increased by 6.7% per year ( < 0.001). Intrahepatic ductal carcinoma incidence increased by 8.9% per year throughout the study period. The rise in incidence was observed in all age groups; however, in age groups < 50 and between 70 and 79 years, observed changes were not statistically significant. For mortality, the significant point of trend change was detected in 2001, where after stable mortality, rates started to increase by 2.4% per year. : Primary liver cancer incidence and mortality increased in both sexes in Lithuania. The rise om incidence was observed in both sexes and main histology groups. The increasing incidence trend may be related to the prevalence of main risk factors (alcohol consumption, hepatitis B and C infections. and diabetes).
: 最近有报道称，在过去几十年中，发达国家的肝癌发病率有所上升；报告称肝细胞癌和胆管癌的发病率有所上升。本研究旨在通过性别、年龄和组织学检查，研究 1998-2015 年期间立陶宛肝癌发病率和死亡率的时间趋势。: 我们使用立陶宛癌症登记处的数据，检查了 1998 年至 2015 年的肝癌发病率。按性别、年龄和组织学计算了年龄标准化发病率。使用 Joinpoint 回归程序分析趋势，以估计每年的百分比变化。: 共诊断出 3086 例原发性肝癌病例，2923 例患者死于肝癌。肝癌病例总数从 1998 年的 132 例增加到 2015 年的 239 例。在研究期间，肝癌发病率从 1998 年的男性 5.02/100000 上升到 2015 年的 10.54/100000，从 1998 年的女性 2.43/100000 上升到 2015 年的 6.25/100000。在此期间，年龄标准化率的年百分比变化（APC）为 4.5%用于发病率和 3.6%用于死亡率。1998 年至 2005 年期间，肝细胞癌发病率稳定（APC-5.9，=0.1），此后每年增加 6.7%（<0.001）。肝内胆管癌的发病率在整个研究期间每年增加 8.9%。在所有年龄组中都观察到发病率上升；然而，在<50 岁和 70-79 岁年龄组，观察到的变化没有统计学意义。对于死亡率，趋势变化的显著点在 2001 年被检测到，此后，死亡率开始每年增加 2.4%。: 立陶宛男女肝癌发病率和死亡率均有所上升。男女两性和主要组织学组均观察到发病率上升。发病率上升趋势可能与主要危险因素（饮酒、乙型肝炎和丙型肝炎感染以及糖尿病）的流行有关。
