Institute for Biology-Bacterial Physiology, Humboldt-Universität zu Berlin, Philippstr. 13, 10115 Berlin, Germany.
Biomolecules. 2021 Jan 29;11(2):186. doi: 10.3390/biom11020186.
The bacterial flagellum and the related virulence-associated injectisome system of pathogenic bacteria utilize a type III secretion system (T3SS) to export substrate proteins across the inner membrane in a proton motive force-dependent manner. The T3SS is composed of an export gate (FliPQR/FlhA/FlhB) located in the flagellar basal body and an associated soluble ATPase complex in the cytoplasm (FliHIJ). Here, we summarise recent insights into the structure, assembly and protein secretion mechanisms of the T3SS with a focus on energy transduction and protein transport across the cytoplasmic membrane.
细菌鞭毛和相关的致病性细菌毒力相关注入系统利用 III 型分泌系统（T3SS）以质子动力势依赖的方式将底物蛋白穿过内膜输出。T3SS 由位于鞭毛基体中的出口门（FliPQR/FlhA/FlhB）和细胞质中的相关可溶性 ATP 酶复合物（FliHIJ）组成。在这里，我们总结了最近关于 T3SS 的结构、组装和蛋白分泌机制的研究进展，重点介绍了能量转导和细胞质膜蛋白运输。
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