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莱姆病中的关节炎与诊断

Arthritis and Diagnostics in Lyme Disease.

作者信息

Quintero Javier A, Attah Raluchukwu, Khianey Reena, Capitle Eugenio, Schutzer Steven E

机构信息

Division of Rheumatology, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

Department of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

出版信息

Trop Med Infect Dis. 2021 Jan 29;6(1):18. doi: 10.3390/tropicalmed6010018.

DOI:10.3390/tropicalmed6010018
PMID:33572912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7931108/
Abstract

The diagnosis of Lyme disease, caused by is clinical but frequently supported by laboratory tests. Lyme arthritis is now less frequently seen than at the time of its discovery. However, it still occurs, and it is important to recognize this, the differential diagnoses, and how laboratory tests can be useful and their limitations. The most frequently used diagnostic tests are antibody based. However, antibody testing still suffers from many drawbacks and is only an indirect measure of exposure. In contrast, evolving direct diagnostic methods can indicate active infection.

摘要

由[病原体名称未给出]引起的莱姆病的诊断主要基于临床症状,但实验室检查也常常提供支持。如今,莱姆关节炎的发病率相较于刚发现时已有所降低。然而,它仍有发生,认识到这一点、其鉴别诊断以及实验室检查如何发挥作用及其局限性很重要。最常用的诊断测试是基于抗体的。然而,抗体检测仍存在许多缺陷,只是对接触情况的一种间接测量。相比之下,不断发展的直接诊断方法能够指示活动性感染。

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本文引用的文献

1
Updated CDC Recommendation for Serologic Diagnosis of Lyme Disease.美国疾病预防控制中心更新莱姆病血清学诊断建议。
MMWR Morb Mortal Wkly Rep. 2019 Aug 16;68(32):703. doi: 10.15585/mmwr.mm6832a4.
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Direct Diagnostic Tests for Lyme Disease.直接诊断莱姆病的检测方法。
Clin Infect Dis. 2019 Mar 5;68(6):1052-1057. doi: 10.1093/cid/ciy614.
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Laboratory diagnosis of Lyme borreliosis: Current state of the art and future perspectives.莱姆病的实验室诊断:现状与未来展望。
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Advances in Serodiagnostic Testing for Lyme Disease Are at Hand.莱姆病血清学诊断检测的进展近在咫尺。
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Clin Infect Dis. 2017 Apr 15;64(8):1074-1080. doi: 10.1093/cid/cix043.
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The Accuracy of Diagnostic Tests for Lyme Disease in Humans, A Systematic Review and Meta-Analysis of North American Research.人类莱姆病诊断测试的准确性:北美研究的系统评价和荟萃分析
PLoS One. 2016 Dec 21;11(12):e0168613. doi: 10.1371/journal.pone.0168613. eCollection 2016.
8
Current Guidelines, Common Clinical Pitfalls, and Future Directions for Laboratory Diagnosis of Lyme Disease, United States.美国莱姆病实验室诊断的现行指南、常见临床陷阱及未来方向
Emerg Infect Dis. 2016 Jul;22(7):1169-77. doi: 10.3201/eid2207.151694.
9
Lyme Borreliosis--the Utility of Improved Real-Time PCR Assay in the Detection of Borrelia burgdorferi Infections.莱姆病螺旋体病——改进的实时聚合酶链反应检测法在检测伯氏疏螺旋体感染中的应用
Adv Clin Exp Med. 2015 Jul-Aug;24(4):663-70. doi: 10.17219/acem/28625.
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Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease.用于改善早期莱姆病中伯氏疏螺旋体感染检测的多抗原检测板的开发。
J Clin Microbiol. 2015 Dec;53(12):3834-41. doi: 10.1128/JCM.02111-15. Epub 2015 Oct 7.