Meerson F Z, Malyshev I Iu, Belkina L M, Saltykova V A
Kardiologiia. 1988 Jan;28(1):70-4.
Adaptation to short-term nondamaging stress effects largely limits or prevents cardiac arrhythmias in acute ischemia and reperfusion. The study examines to what extent this anti-arrhythmic effect depends on adaptational shifts of the heart itself. Isolated hearts of animals adapted to stress are shown to possess dramatically increased resistance to arrhythmias induced by local ischemia and reperfusion. The role of activated prostaglandin biosynthesis, adenosine, antioxidant systems, desensitization and other protective control systems functioning at heart level to provide this anti-arrhythmic effect is discussed.
对短期无损伤应激效应的适应在很大程度上限制或预防急性缺血和再灌注时的心律失常。本研究探讨这种抗心律失常效应在多大程度上依赖于心脏自身的适应性变化。结果显示，适应应激的动物离体心脏对局部缺血和再灌注诱导的心律失常具有显著增强的抵抗力。文中讨论了活化的前列腺素生物合成、腺苷、抗氧化系统、脱敏作用以及其他在心脏水平发挥作用以提供这种抗心律失常效应的保护控制系统的作用。
