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通过对短暂应激暴露进行预先适应和使用抗氧化剂维生素E预防实验性心肌梗死中心脏电稳定性紊乱

[Prevention of a disorder in the electrical stability of the heart in experimental myocardial infarct by using preliminary adaptation to brief stress exposures and the antioxidant ionol].

作者信息

Meerson F Z, Belkina L M, Diusenov S S, Saltykova V A, Shabunina E V

出版信息

Kardiologiia. 1986 Aug;26(8):19-24.

PMID:3761844
Abstract

Preliminary adaptation to short-term stress was shown to prevent the fall of the heart fibrillation threshold and its increased ectopic activity which is usually observed in experimental myocardial infarction. This protective effect involves an enhanced activity of the organism's antioxidant systems. On this basis, synthetic antioxidant ionol was applied to prevent disturbances of heart electric stability in infarction. Ionol completely prevented the decrease in the electric threshold and the increase in ectopic activity of the heart in experimental infarction, demonstrating thereby an anti-arrhythmic effect.

摘要

初步适应短期应激可防止实验性心肌梗死中通常观察到的房颤阈值下降及其异位活动增加。这种保护作用涉及机体抗氧化系统活性增强。在此基础上，应用合成抗氧化剂ionol预防梗死时心脏电稳定性的紊乱。Ionol完全防止了实验性梗死中电阈值的降低和心脏异位活动的增加，从而证明了其抗心律失常作用。

相似文献

1
[Prevention of a disorder in the electrical stability of the heart in experimental myocardial infarct by using preliminary adaptation to brief stress exposures and the antioxidant ionol].通过对短暂应激暴露进行预先适应和使用抗氧化剂维生素E预防实验性心肌梗死中心脏电稳定性紊乱
Kardiologiia. 1986 Aug;26(8):19-24.
2
[Effect of adaptation to short-term stress exposure on the fibrillation threshold and ectopic activity of the heart in experimental myocardial infarct].[短期应激暴露适应对实验性心肌梗死心脏颤动阈值和异位活动的影响]
Biull Eksp Biol Med. 1987 Mar;103(3):271-3.
3
[Prevention of disorders in the contractile function of the nonischemic portion of the heart during infarction by preliminary adaptation to brief stress exposures].
Biull Eksp Biol Med. 1985 Jun;99(6):667-9.
4
[Prevention of heart contractile function disorders in myocardial infarct by preliminary adaptation to brief stress exposures].
Patol Fiziol Eksp Ter. 1985 May-Jun(3):9-13.
5
[Enhanced resistance of the heart to arrhythmogenic factors as affected by adaptation of the body to stress exposures].[身体对压力暴露的适应对心脏抗致心律失常因素能力的增强作用]
Kardiologiia. 1988 Jan;28(1):70-4.
6
[Elimination of disorders of electric stability of the heart during post-infarct cardiosclerosis using adaptation to short-term stress and the antioxidant ionol].[通过适应短期应激和使用抗氧化剂维生素E消除心肌梗死后心肌硬化期间心脏电稳定性障碍]
Biull Eksp Biol Med. 1986 Nov;102(11):536-9.
7
[Prevention of ischemic and re-oxygenation arrhythmias and heart fibrillation using the antioxidant ionol].[使用抗氧化剂维生素E防止缺血及再给氧引起的心律失常和心房纤颤]
Biull Eksp Biol Med. 1986 Jun;101(6):662-4.
8
[Prevention of disorders of the electric stability of the heart in experimental infarct using adaptation to hypoxia].[利用缺氧适应预防实验性梗死中心脏电稳定性紊乱]
Biull Eksp Biol Med. 1988 Apr;105(4):401-3.
9
[Prevention of cardiac fibrillation using antioxidants and preliminary adaptation of animals to the effects of stress].[使用抗氧化剂预防心脏纤颤及动物对应激作用的初步适应性]
Kardiologiia. 1985 Oct;25(10):29-34.
10
[Disordered cardiac electrical stability in beta-adrenergic damage and antioxidant protection].[β-肾上腺素能损伤中的心脏电稳定性紊乱与抗氧化保护]
Biull Eksp Biol Med. 1991 Nov;112(11):465-7.

引用本文的文献

1
Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca2+ on the heart by the increased activity of sarcoplasmic reticulum.对压力暴露的适应可通过增加肌浆网的活性来防止过量钙离子对心脏产生致心律失常和收缩的影响。
Basic Res Cardiol. 1990 Jan-Feb;85(1):96-103. doi: 10.1007/BF01907018.