通过对短暂应激暴露进行预先适应和使用抗氧化剂维生素E预防实验性心肌梗死中心脏电稳定性紊乱

[Prevention of a disorder in the electrical stability of the heart in experimental myocardial infarct by using preliminary adaptation to brief stress exposures and the antioxidant ionol].

作者信息

Meerson F Z, Belkina L M, Diusenov S S, Saltykova V A, Shabunina E V

出版信息

Kardiologiia. 1986 Aug;26(8):19-24.

Abstract

Preliminary adaptation to short-term stress was shown to prevent the fall of the heart fibrillation threshold and its increased ectopic activity which is usually observed in experimental myocardial infarction. This protective effect involves an enhanced activity of the organism's antioxidant systems. On this basis, synthetic antioxidant ionol was applied to prevent disturbances of heart electric stability in infarction. Ionol completely prevented the decrease in the electric threshold and the increase in ectopic activity of the heart in experimental infarction, demonstrating thereby an anti-arrhythmic effect.

摘要

初步适应短期应激可防止实验性心肌梗死中通常观察到的房颤阈值下降及其异位活动增加。这种保护作用涉及机体抗氧化系统活性增强。在此基础上，应用合成抗氧化剂ionol预防梗死时心脏电稳定性的紊乱。Ionol完全防止了实验性梗死中电阈值的降低和心脏异位活动的增加，从而证明了其抗心律失常作用。

相似文献

1

[Prevention of a disorder in the electrical stability of the heart in experimental myocardial infarct by using preliminary adaptation to brief stress exposures and the antioxidant ionol].通过对短暂应激暴露进行预先适应和使用抗氧化剂维生素E预防实验性心肌梗死中心脏电稳定性紊乱

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引用本文的文献

1

Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca2+ on the heart by the increased activity of sarcoplasmic reticulum.对压力暴露的适应可通过增加肌浆网的活性来防止过量钙离子对心脏产生致心律失常和收缩的影响。

Basic Res Cardiol. 1990 Jan-Feb;85(1):96-103. doi: 10.1007/BF01907018.

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