Department of Immunology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, TajGanj, Agra, India.
Scand J Immunol. 2012 Apr;75(4):369-78. doi: 10.1111/j.1365-3083.2012.02677.x.
Although Mycobacterium leprae was the first bacterial pathogen identified causing human disease, it remains one of the few that is non-cultivable. Understanding the biology of M. leprae is one of the primary challenges in current leprosy research. Genomics has been extremely valuable, nonetheless, functional proteins are ultimately responsible for controlling most aspects of cellular functions, which in turn could facilitate parasitizing the host. Furthermore, bacterial proteins provide targets for most of the vaccines and immunodiagnostic tools. Better understanding of the proteomics of M. leprae could also help in developing new drugs against M. leprae. During the past nearly 15 years, there have been several developments towards the identification of M. leprae proteins employing contemporary proteomics tools. In this review, we discuss the knowledge gained on the biology and pathogenesis of M. leprae from current proteomic studies.
虽然麻风分枝杆菌是第一个被确定导致人类疾病的细菌病原体，但它仍然是少数几种不能培养的病原体之一。了解麻风分枝杆菌的生物学特性是当前麻风病研究的主要挑战之一。基因组学非常有价值，然而，功能蛋白最终负责控制细胞功能的大多数方面，这反过来又可以帮助其寄生宿主。此外，细菌蛋白为大多数疫苗和免疫诊断工具提供了靶点。更好地了解麻风分枝杆菌的蛋白质组学也有助于开发针对麻风分枝杆菌的新药。在过去的近 15 年中，已经有几种利用现代蛋白质组学工具来鉴定麻风分枝杆菌蛋白的方法得到了发展。在这篇综述中，我们讨论了从当前的蛋白质组学研究中获得的关于麻风分枝杆菌生物学和发病机制的知识。
