Department of Surgical Oncology, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Support Care Cancer. 2023 Oct 28;31(12):660. doi: 10.1007/s00520-023-08134-2.
Oxaliplatin-induced peripheral neuropathy (OIPN) is a common and dose-limiting toxicity that markedly limits the use of oxaliplatin and affects quality of life. Statins have been shown to exert neuroprotective effects in preclinical settings. The aim of the present study was to clarify whether statins prevented OIPN in patients with colorectal cancer (CRC) receiving adjuvant CAPOX therapy.
We examined 224 patients who received adjuvant CAPOX therapy for CRC between July 2010 and December 2021 at our hospital. Patients were divided into "Statin" and "Non-statin" groups based on statin use. Details on and the adverse events of adjuvant CAPOX therapy were examined in association with statin use.
Thirty-one patients (14%) were treated with statins. There were no intergroup differences in the relative dose intensity or number of CAPOX cycles between the Statin and Non-statin groups. In total, 94% of patients in the Statin group and 95% of those in the Non-statin group developed OIPN (p=0.67). The severity of OIPN was similar between the two groups (p=0.89). The frequency of treatment delays in CAPOX did not significantly differ between the Statin and Non-statin groups (16% vs. 11%, p=0.45).
The efficacy of statins to attenuate OIPN during adjuvant CAPOX therapy was not apparent in the current study. Further studies are needed to confirm the present results.
奥沙利铂诱导的周围神经病变（OIPN）是一种常见的剂量限制毒性，显著限制了奥沙利铂的应用，并影响了生活质量。他汀类药物已被证明在临床前环境中具有神经保护作用。本研究旨在阐明他汀类药物是否能预防接受辅助 CAPOX 治疗的结直肠癌（CRC）患者的 OIPN。
我们检查了 2010 年 7 月至 2021 年 12 月期间在我院接受辅助 CAPOX 治疗的 224 例 CRC 患者。根据他汀类药物的使用情况，将患者分为“他汀类”和“非他汀类”两组。检查了辅助 CAPOX 治疗的详细信息和不良事件与他汀类药物使用的关系。
31 例（14%）患者接受了他汀类药物治疗。他汀类药物组和非他汀类药物组之间，CAPOX 的相对剂量强度或周期数均无组间差异。他汀类药物组 94%的患者和非他汀类药物组 95%的患者发生 OIPN（p=0.67）。两组 OIPN 的严重程度相似（p=0.89）。CAPOX 治疗的延迟频率在他汀类药物组和非他汀类药物组之间没有显著差异（16%比 11%，p=0.45）。
在本研究中，他汀类药物在辅助 CAPOX 治疗中减轻 OIPN 的疗效并不明显。需要进一步的研究来证实目前的结果。
