Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
Science. 2021 Feb 12;371(6530). doi: 10.1126/science.abd0951.
Circadian clocks temporally coordinate physiology and align it with geophysical time, which enables diverse life-forms to anticipate daily environmental cycles. In complex organisms, clock function originates from the molecular oscillator within each cell and builds upward anatomically into an organism-wide system. Recent advances have transformed our understanding of how clocks are connected to achieve coherence across tissues. Circadian misalignment, often imposed in modern society, disrupts coordination among clocks and has been linked to diseases ranging from metabolic syndrome to cancer. Thus, uncovering the physiological circuits whereby biological clocks achieve coherence will inform on both challenges and opportunities in human health.
生物钟使生理机能与地球物理时间同步，从而使各种生物能够预测日常环境周期。在复杂的生物体中，生物钟功能源自每个细胞内的分子振荡器，并在解剖结构上向上构建为全器官系统。最近的进展改变了我们对时钟如何连接以实现组织间一致性的理解。生物钟的错位，通常是在现代社会中产生的，打乱了时钟之间的协调，并与从代谢综合征到癌症等各种疾病有关。因此，揭示生物钟实现一致性的生理回路将为人类健康带来挑战和机遇。
