昼夜节律时钟及其在跨器官系统的肾脏和眼部疾病中的作用。
Circadian clocks and their role in kidney and eye diseases across organ systems.
作者信息
Chen Xiuli, Zhang Wenxiao, Gu Yue, Huang Shenzhen
机构信息
Department of Gynecology and Obstetrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine of Henan University, Zhengzhou, Henan, China.
Department of Ophthalmology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
出版信息
Front Physiol. 2025 May 27;16:1583502. doi: 10.3389/fphys.2025.1583502. eCollection 2025.
Circadian rhythms, the body's intrinsic 24-h cycles, regulate essential physiological processes across multiple organ systems. Disruptions in these rhythms are increasingly recognized as significant contributors to chronic kidney disease and ocular diseases such as glaucoma, dry eye disease, and diabetic retinopathy. This review examines the interconnections between circadian rhythms in kidney and eye health, focusing on shared pathological pathways including oxidative stress, inflammation, and fibrosis. Current therapeutic strategies such as chronotherapy, light therapy, and time-restricted feeding show promise in mitigating disease progression by restoring circadian alignment. This review emphasizes integrated circadian-focused treatments to address these co-morbid conditions, paving the way for novel preventive and therapeutic interventions.
昼夜节律是人体内在的24小时周期，调节着多个器官系统的基本生理过程。这些节律的紊乱日益被认为是慢性肾脏病以及青光眼、干眼症和糖尿病视网膜病变等眼部疾病的重要促成因素。本综述探讨了肾脏和眼部健康中的昼夜节律之间的相互联系，重点关注包括氧化应激、炎症和纤维化在内的共同病理途径。当前的治疗策略，如时间疗法、光疗法和限时进食，在通过恢复昼夜节律同步来减轻疾病进展方面显示出前景。本综述强调以昼夜节律为重点的综合治疗，以应对这些共病状况，为新的预防和治疗干预措施铺平道路。
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