Guy´s & St Thomas´ Hospital NHS Foundation Trust, Oral Surgery, Great Maze Pond, SE1 9RT, London, UK.
Oral and Maxillofacial Head and Neck Surgery, Homerton University Hospital NHS Foundation Trust, E9 6SR, London, UK.
Br Dent J. 2021 Feb;230(3):143-147. doi: 10.1038/s41415-021-2601-3. Epub 2021 Feb 12.
Sickle cell disease is a multisystem disease associated with episodes of acute illness and progressive organ damage. It is one of the most common severe monogenic disorders worldwide and is now the fastest growing genetic disorder in the UK. Dental awareness of orofacial manifestation varies geographically due to the inheritance pattern and patient population affected by the disease. This article details the epidemiology, pathophysiology and the orofacial manifestations in light of current literature.
镰状细胞病是一种多系统疾病，与急性疾病发作和进行性器官损伤有关。它是世界上最常见的严重单基因疾病之一，也是目前英国增长最快的遗传性疾病。由于疾病的遗传模式和受影响的患者人群，口腔对口腔表现的认识在地理上有所不同。本文详细介绍了流行病学、病理生理学以及当前文献中的口腔表现。
