Lopresti Natalie M, Esguerra Manuel, Mermelstein Paul G
University of Minnesota, Twin Cities, Department of Neuroscience.
Curr Sex Health Rep. 2020 Sep;12(3):186-194. doi: 10.1007/s11930-020-00266-4. Epub 2020 Jul 17.
This review aims to discuss sex differences observed in preclinical rodent models of opioid reward.
Utilizing a variety of methodological approaches and drug regimens, no clear consensus has emerged regarding the effects of opiates between males and females. This is quite dissimilar to work examining psychostimulants, where female animals reliably exhibit stronger behavioral responses.
With opioid research quickly expanding to determine the neural underpinnings of opioid addiction, further research is essential to determine the conditions wherein sex differences may occur and how they may relate to the human condition.
本综述旨在探讨在阿片类奖赏的临床前啮齿动物模型中观察到的性别差异。
利用多种方法和药物方案，关于雄性和雌性之间阿片类药物的作用尚未形成明确的共识。这与研究精神兴奋剂的工作大不相同，在研究精神兴奋剂时，雌性动物确实表现出更强的行为反应。
随着阿片类药物研究迅速扩展以确定阿片类药物成瘾的神经基础，进一步的研究对于确定可能出现性别差异的条件以及它们与人类情况的关系至关重要。
