阿片类奖赏动物模型中的性别差异。
Sex Differences in Animal Models of Opioid Reward.
作者信息
Lopresti Natalie M, Esguerra Manuel, Mermelstein Paul G
机构信息
University of Minnesota, Twin Cities, Department of Neuroscience.
出版信息
Curr Sex Health Rep. 2020 Sep;12(3):186-194. doi: 10.1007/s11930-020-00266-4. Epub 2020 Jul 17.
Abstract
PURPOSE OF REVIEW
This review aims to discuss sex differences observed in preclinical rodent models of opioid reward.
RECENT FINDINGS
Utilizing a variety of methodological approaches and drug regimens, no clear consensus has emerged regarding the effects of opiates between males and females. This is quite dissimilar to work examining psychostimulants, where female animals reliably exhibit stronger behavioral responses.
SUMMARY
With opioid research quickly expanding to determine the neural underpinnings of opioid addiction, further research is essential to determine the conditions wherein sex differences may occur and how they may relate to the human condition.
摘要
综述目的
本综述旨在探讨在阿片类奖赏的临床前啮齿动物模型中观察到的性别差异。
最新发现
利用多种方法和药物方案，关于雄性和雌性之间阿片类药物的作用尚未形成明确的共识。这与研究精神兴奋剂的工作大不相同，在研究精神兴奋剂时，雌性动物确实表现出更强的行为反应。
总结
随着阿片类药物研究迅速扩展以确定阿片类药物成瘾的神经基础，进一步的研究对于确定可能出现性别差异的条件以及它们与人类情况的关系至关重要。
相似文献
1
Sex Differences in Animal Models of Opioid Reward.
Curr Sex Health Rep. 2020 Sep;12(3):186-194. doi: 10.1007/s11930-020-00266-4. Epub 2020 Jul 17.
2
Sex-specific responses to opiates: animal and human studies.
Anesth Analg. 2008 Jul;107(1):83-95. doi: 10.1213/ane.0b013e31816a66a4.
3
The Protective Effect of Social Reward on Opioid and Psychostimulant Reward and Relapse: Behavior, Pharmacology, and Brain Regions.
J Neurosci. 2022 Dec 14;42(50):9298-9314. doi: 10.1523/JNEUROSCI.0931-22.2022.
4
Robust age, but limited sex, differences in mu-opioid receptors in the rat brain: relevance for reward and drug-seeking behaviors in juveniles.
Brain Struct Funct. 2018 Jan;223(1):475-488. doi: 10.1007/s00429-017-1498-8. Epub 2017 Sep 4.
5
Biological basis of sex differences in drug abuse: preclinical and clinical studies.
Psychopharmacology (Berl). 2002 Nov;164(2):121-37. doi: 10.1007/s00213-002-1183-2. Epub 2002 Sep 5.
6
Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction.
Front Neurosci. 2015 Dec 16;9:466. doi: 10.3389/fnins.2015.00466. eCollection 2015.
7
Exercise as a Prevention for Substance Use Disorder: A Review of Sex Differences and Neurobiological Mechanisms.
Curr Addict Rep. 2017 Dec;4(4):455-466. doi: 10.1007/s40429-017-0178-3. Epub 2017 Nov 2.
8
15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse.
Neuropharmacology. 2014 Jan;76 Pt B(0 0):204-17. doi: 10.1016/j.neuropharm.2013.08.028. Epub 2013 Sep 10.
9
Behavioral sex differences in cocaine and opioid use disorders: The role of gonadal hormones.
Neurosci Biobehav Rev. 2021 Sep;128:358-366. doi: 10.1016/j.neubiorev.2021.06.038. Epub 2021 Jun 29.
10
Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice.
Genes Brain Behav. 2021 Mar;20(3):e12711. doi: 10.1111/gbb.12711. Epub 2020 Nov 23.
引用本文的文献
1
Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males.
Neuron. 2025 May 7;113(9):1413-1429.e5. doi: 10.1016/j.neuron.2025.02.013. Epub 2025 Mar 10.
2
Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia.
Nat Ment Health. 2024 Sep;2(9):1018-1031. doi: 10.1038/s44220-024-00278-2. Epub 2024 Jul 9.
3
Molecular Sex Differences and Clinical Gender Efficacy in Opioid Use Disorders: From Pain Management to Addiction.
Int J Mol Sci. 2024 Aug 28;25(17):9314. doi: 10.3390/ijms25179314.
4
Magnitude and predictors of elasticity of demand for morphine are similar in male and female rats.
Front Behav Neurosci. 2024 Aug 29;18:1443364. doi: 10.3389/fnbeh.2024.1443364. eCollection 2024.
5
Sex differences in comorbid pain and opioid use disorder: A scoping review.
Br J Clin Pharmacol. 2024 Dec;90(12):3067-3083. doi: 10.1111/bcp.16218. Epub 2024 Aug 21.
6
ERα Stimulation Rapidly Modulates Excitatory Synapse Properties in Female Rat Nucleus Accumbens Core.
Neuroendocrinology. 2023;113(11):1140-1153. doi: 10.1159/000529571. Epub 2023 Feb 6.
7
Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.
NMR Biomed. 2023 Feb;36(2):e4842. doi: 10.1002/nbm.4842. Epub 2022 Nov 23.
8
Sex differences in opioid receptor mediated effects: Role of androgens.
Neurosci Biobehav Rev. 2022 Mar;134:104522. doi: 10.1016/j.neubiorev.2022.104522. Epub 2022 Jan 4.
9
The effects of chronic estradiol treatment on opioid self-administration in intact female rats.
Drug Alcohol Depend. 2021 Aug 1;225:108816. doi: 10.1016/j.drugalcdep.2021.108816. Epub 2021 Jun 18.
本文引用的文献
1
Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice.
Eur J Neurosci. 2020 Feb;51(3):742-754. doi: 10.1111/ejn.14580. Epub 2019 Oct 6.
2
Social dominance hierarchy type and rank contribute to phenotypic variation within cages of laboratory mice.
Sci Rep. 2019 Sep 20;9(1):13650. doi: 10.1038/s41598-019-49612-0.
3
Are hormones a "female problem" for animal research?
Science. 2019 May 31;364(6443):825-826. doi: 10.1126/science.aaw7570.
4
Programming of Dopaminergic Neurons by Early Exposure to Sex Hormones: Effects on Morphine-Induced Accumbens Dopamine Release, Reward, and Locomotor Behavior in Male and Female Rats.
Front Pharmacol. 2019 Mar 26;10:295. doi: 10.3389/fphar.2019.00295. eCollection 2019.
5
Peripubertal stress of male, but not female rats increases morphine-induced conditioned place preference and locomotion in adulthood.
Dev Psychobiol. 2019 Sep;61(6):920-929. doi: 10.1002/dev.21839. Epub 2019 Mar 12.
6
Biological Sex, Estradiol and Striatal Medium Spiny Neuron Physiology: A Mini-Review.
Front Cell Neurosci. 2018 Dec 12;12:492. doi: 10.3389/fncel.2018.00492. eCollection 2018.
7
Drug and Opioid-Involved Overdose Deaths - United States, 2013-2017.
MMWR Morb Mortal Wkly Rep. 2018 Jan 4;67(5152):1419-1427. doi: 10.15585/mmwr.mm675152e1.
8
Systematic review of sex-based differences in opioid-based effects.
Int Rev Psychiatry. 2018 Oct;30(5):107-116. doi: 10.1080/09540261.2018.1514295. Epub 2018 Dec 6.
9
Estrogen Regulation of GRK2 Inactivates Kappa Opioid Receptor Signaling Mediating Analgesia, But Not Aversion.
J Neurosci. 2018 Sep 12;38(37):8031-8043. doi: 10.1523/JNEUROSCI.0653-18.2018. Epub 2018 Aug 3.
10
Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females.
Horm Behav. 2018 Aug;104:130-137. doi: 10.1016/j.yhbeh.2018.03.001. Epub 2018 Mar 10.
Zotero 插件