Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Pain Res Manag. 2021 Jan 28;2021:1541748. doi: 10.1155/2021/1541748. eCollection 2021.
Smoking is clinically associated with high postoperative pain scores and increased perioperative analgesic requirements. However, the association between the duration of smoking cessation and postoperative opioid requirements remains unclear. Therefore, this study aimed to evaluate the association between the duration of smoking cessation and postoperative opioid requirements. We retrospectively analyzed the data of 144 male patients who received intravenous patient-controlled analgesia (IV PCA) after laparoscopic distal gastrectomy with gastroduodenostomy. All patients were divided into three groups: G0, nonsmoker; G1, smoker who quit smoking within 1 month preoperatively; G2, smoker who quit smoking over 1 month preoperatively. Analgesic use, pain intensity, and IV PCA side effects were assessed up to postoperative day 2. As the duration of smoking cessation increased, the amount of postoperative opioid consumption decreased ( = -0.08; 95% confidence interval (CI), -0.11 to -0.04; < 0.001). The total postoperative opioid requirements in G1 were significantly higher than those in G0 and G2 (G0, 75.5 ± 15.9 mg; G1, 94.6 ± 20.5 mg; and G2, 79.9 ± 19.4 mg ( < 0.001)). A multivariate regression analysis revealed that G1 was independently associated with increased postoperative opioid requirements ( = 12.80; 95% CI, 5.81-19.80; < 0.001). Consequently, male patients who had ceased smoking within 1 month of undergoing a laparoscopic distal gastrectomy with gastroduodenostomy had higher postoperative opioid use than patients who had ceased smoking for more than 1 month and nonsmokers.
吸烟与术后高疼痛评分和增加围手术期镇痛需求相关。然而，戒烟持续时间与术后阿片类药物需求之间的关系仍不清楚。因此，本研究旨在评估戒烟持续时间与术后阿片类药物需求之间的关系。我们回顾性分析了 144 例接受腹腔镜胃远端切除术伴胃十二指肠吻合术后静脉患者自控镇痛（IV PCA）的男性患者的数据。所有患者被分为三组：G0，非吸烟者；G1，术前 1 个月内戒烟的吸烟者；G2，术前戒烟超过 1 个月的吸烟者。评估术后第 2 天之前的镇痛药物使用、疼痛强度和 IV PCA 副作用。随着戒烟持续时间的增加，术后阿片类药物消耗量减少（ = -0.08；95%置信区间（CI），-0.11 至-0.04； < 0.001）。G1 的总术后阿片类药物需求明显高于 G0 和 G2（G0，75.5±15.9mg；G1，94.6±20.5mg；G2，79.9±19.4mg（ < 0.001））。多变量回归分析显示，G1 与术后阿片类药物需求增加独立相关（ = 12.80；95%CI，5.81-19.80； < 0.001）。因此，与戒烟超过 1 个月和不吸烟者相比，接受腹腔镜胃远端切除术伴胃十二指肠吻合术的男性患者，在术后 1 个月内戒烟的患者术后阿片类药物使用量更高。
