Nakajima Motohiro, Al'Absi Mustafa
Duluth Medical Research Institute, Department of Biobehavioral Health and Population Sciences, University of Minnesota Medical School, Duluth, Minnesota, USA.
Psychophysiology. 2014 Oct;51(10):1015-22. doi: 10.1111/psyp.12241. Epub 2014 Jun 17.
Chronic smoking has been linked with alterations in endogenous pain regulation. These alterations may be pronounced when individuals quit smoking because nicotine withdrawal produces a variety of psychological and physiological symptoms. Smokers interested in quitting (n = 98) and nonsmokers (n = 37) completed a laboratory session including cold pressor test (CPT) and heat thermal pain. Smokers set a quit date and completed the session after 48 h of abstinence. Participants completed the pain assessments once after rest and once after stress. Cardiovascular and nicotine withdrawal measures were collected. Smokers showed blunted cardiovascular responses to stress relative to nonsmokers. Only nonsmokers had greater pain tolerance to CPT after stress than after rest. Lower systolic blood pressure was related to lower pain tolerance. These findings suggest that smoking withdrawal is associated with blunted stress response and increased pain sensitivity.
长期吸烟与内源性疼痛调节的改变有关。当个体戒烟时，这些改变可能会很明显，因为尼古丁戒断会产生各种心理和生理症状。有意戒烟的吸烟者（n = 98）和非吸烟者（n = 37）完成了一次实验室测试，包括冷加压试验（CPT）和热痛觉测试。吸烟者设定了戒烟日期，并在戒烟48小时后完成测试。参与者在休息后和应激后各完成一次疼痛评估。同时收集心血管和尼古丁戒断指标。与非吸烟者相比，吸烟者对应激的心血管反应减弱。只有非吸烟者在应激后对CPT的疼痛耐受性比休息后更高。较低的收缩压与较低的疼痛耐受性相关。这些发现表明，戒烟与应激反应减弱和疼痛敏感性增加有关。
