Amini Arya, Freeman Morganna, Melstrom Laleh, Margolin Kim A, Parekh Vishwas, Abdulla Farah R, Modi Badri
Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Mol Clin Oncol. 2021 Mar;14(3):46. doi: 10.3892/mco.2021.2208. Epub 2021 Jan 13.
In locally advanced basal cell carcinoma (BCC) patients who are not surgical candidates and where radiation therapy (RT) alone would offer lower control rates, the combination of vismodegib and RT delivered concurrently may potentially improve outcomes compared to single modality treatment. The current study presents a case of very advanced, multifocal BCC who received concurrent vismodegib and RT. The patient initially came in with four large primary areas of disease including the left preauriculum, right shoulder, chest wall and right lateral ankle. All sites achieved a clinical complete response, with a pathologic complete response at the right shoulder. The ankle lesion did not require RT and continues to have a clinical complete response. The findings from our case report support several other cases with similar efficacy when vismodegib and RT are combined.
在不适合手术且单纯放疗控制率较低的局部晚期基底细胞癌（BCC）患者中，与单一治疗方式相比，维莫德吉与放疗同时进行可能会改善治疗效果。本研究报告了一例接受维莫德吉与放疗联合治疗的极晚期、多灶性BCC病例。该患者最初就诊时，有四个大的原发性病灶区域，包括左耳前、右肩、胸壁和右外踝。所有部位均达到临床完全缓解，右肩达到病理完全缓解。踝关节病变无需放疗，目前仍保持临床完全缓解。我们病例报告的结果支持了其他几例维莫德吉与放疗联合使用具有相似疗效的病例。
