Jiang Huirong, Tai Zongguang, Chen Zhongjian, Zhu Quangang, Bao Leilei
Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China.
Shanghai Skin Disease Hospital, Tongji University School of Medicine Shanghai 200443, China.
Am J Cancer Res. 2021 Feb 1;11(2):318-336. eCollection 2021.
The renin-angiotensin system (RAS) regulates physiological functions of the cardiovascular system, kidneys, and other tissues. Various and studies have shown that RAS plays a pivotal role in the development of malignant tumors, while several retrospective studies have confirmed that patients undergoing long-term RAS inhibitors (RASi) treatment have a lowered risk of cancer. Moreover, blocking RAS has been shown to inhibit tumor growth, metastasis, and angiogenesis in various experimental models of malignant tumors. Herein, we review the available RASi-related literature and provide an analysis using the scientific atlas software VOSviewer. We observed that recent studies have primarily focused on gene expression, tumor biology, and survival analysis. Through an in-depth data analysis from the Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx), we identified the impact of , an essential component of RAS, on tumors, and we discuss the underlying biological mechanism of RASi. Furthermore, we outline the research progress and potential use of RASi in tumor treatment. Overall, RASi may be a promising adjunct in cancer therapy.
肾素-血管紧张素系统（RAS）调节心血管系统、肾脏及其他组织的生理功能。众多研究表明，RAS在恶性肿瘤的发生发展中起关键作用，而多项回顾性研究证实，接受长期肾素-血管紧张素系统抑制剂（RASi）治疗的患者患癌风险降低。此外，在各种恶性肿瘤实验模型中，阻断RAS已被证明可抑制肿瘤生长、转移和血管生成。在此，我们综述了现有的与RASi相关的文献，并使用科学图谱软件VOSviewer进行分析。我们观察到，近期研究主要集中在基因表达、肿瘤生物学和生存分析方面。通过对癌症基因组图谱（TCGA）和基因型组织表达（GTEx）进行深入数据分析，我们确定了RAS的重要组成部分[此处原文缺失相关内容]对肿瘤的影响，并讨论了RASi的潜在生物学机制。此外，我们概述了RASi在肿瘤治疗中的研究进展和潜在用途。总体而言，RASi可能是癌症治疗中一种有前景的辅助手段。
