Department of Medical Genetics, Nanjing University School of Medicine, Nanjing 210093, China.
Department of Pharmacy, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
J Diabetes Res. 2021 Jan 28;2021:5340453. doi: 10.1155/2021/5340453. eCollection 2021.
Epidemiological data on diabetic retinopathy (DR) in Chinese population is still rather scarce, and risk factors for diabetic retinopathy are inconsistent because of study designs, grading standards, and population samples.
This hospital-based retrospective study included 1052 type 2 diabetes patients. Diabetic retinopathy was diagnosed by nonmydriatic fundus photography and/or fundus examination apparatus. Logistic regression analysis was performed to evaluate the risk of diabetic retinopathy.
A total of 352 (33.5% prevalence) subjects were diagnosed with diabetic retinopathy based on our population. The patients in the DR group not only had significantly higher hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), urinary microalbumin-creatinine ratio (ACR), and systolic blood pressure but also had higher follicle-stimulating hormone (FSH), luteinizing hormone (LH), and sex hormone-binding globulin (SHBG) levels compared to those in the non-DR group. Moreover, we confirmed that diabetes duration and HbA1c are strongly associated with DR risk. We also found that serum LH was an independent risk factor in male diabetic retinopathy patients (OR = 1.086, 95% CI 1.024-1.152), and the levels of LH were significantly associated with diabetic retinopathy prevalence ( = 0.018).
Our study strengthens the argument that diabetes duration and HbA1c are risk factors for patients with DR. Additionally; we firstly confirmed that serum LH was an independent risk factor in male diabetic retinopathy patients.
中国人群的糖尿病视网膜病变（DR）流行病学数据仍然相当匮乏，由于研究设计、分级标准和人群样本的不同，DR 的危险因素也不一致。
本项基于医院的回顾性研究纳入了 1052 例 2 型糖尿病患者。通过免散瞳眼底照相和/或眼底检查仪诊断糖尿病视网膜病变。采用 logistic 回归分析评估糖尿病视网膜病变的风险。
根据我们的人群数据，共有 352 名（患病率 33.5%）患者被诊断为糖尿病视网膜病变。DR 组患者的糖化血红蛋白（HbA1c）、空腹血糖（FPG）、尿微量白蛋白/肌酐比值（ACR）和收缩压显著升高，且卵泡刺激素（FSH）、黄体生成素（LH）和性激素结合球蛋白（SHBG）水平也高于非 DR 组。此外，我们证实糖尿病病程和 HbA1c 与 DR 风险密切相关。我们还发现血清 LH 是男性糖尿病视网膜病变患者的独立危险因素（OR=1.086，95%CI 1.024-1.152），且 LH 水平与糖尿病视网膜病变患病率显著相关（ = 0.018）。
本研究进一步证实了糖尿病病程和 HbA1c 是 DR 患者的危险因素。此外，我们首次证实血清 LH 是男性糖尿病视网膜病变患者的独立危险因素。
