Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284-3068, USA.
Department of Chemistry & Biochemistry, Florida State University, Tallahassee, Florida 32306, USA.
Org Biomol Chem. 2021 Mar 11;19(9):1991-1999. doi: 10.1039/d0ob02591g.
Numerous methodologies to obtain pyridines from ylidenemalononitriles are described in the literature. Nevertheless, they are limited to the use of microwave or conventional heat and few lead to 2,3,4 or 2,3,4,5-substituted pyridines as multi-proposal molecular scaffolds or even universal pyridines. Herein, we present a mild and facile solvent-free methodology to obtain a scope of multi-substituted pyridines at room temperature. We also report an example where one of the resulting amino-nicotinonitriles exhibits a preliminary evidence of aggregation-induced emission (AIE).
文献中描述了许多从亚烯基丙二腈中获得吡啶的方法。然而，这些方法仅限于使用微波或常规加热，并且很少能得到 2,3,4 或 2,3,4,5-取代的吡啶作为多方案的分子支架，甚至是通用的吡啶。在此，我们提出了一种温和、简便的无溶剂方法，可在室温下获得一系列多取代吡啶。我们还报告了一个例子，其中一个得到的氨基烟腈表现出初步的聚集诱导发射（AIE）证据。
