Tobolska Aleksandra, Wezynfeld Nina E, Wawrzyniak Urszula E, Bal Wojciech, Wróblewski Wojciech
Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.
Dalton Trans. 2021 Feb 28;50(8):2726-2730. doi: 10.1039/d0dt03898a. Epub 2021 Feb 12.
Electrochemical and spectroscopic studies demonstrated that the N-truncated amyloid β peptide Aβ (Arg-His-Asp-Ser-Gly-NH) possessing histidine at position 2 (His-2) formed ternary complexes with copper(ii) and phosphate anions or phosphate groups of biomolecules. The recognition ability of Cu(ii)-Aβ toward phosphate species provided a new perspective on designing phosphate-selective molecular receptors.
电化学和光谱研究表明，在第2位含有组氨酸（His-2）的N端截短的淀粉样β肽Aβ（Arg-His-Asp-Ser-Gly-NH）与铜（ii）以及生物分子的磷酸根阴离子或磷酸基团形成三元复合物。Cu（ii）-Aβ对磷酸物种的识别能力为设计磷酸选择性分子受体提供了新的视角。
