Xiao Jingyuan, Cong Hailin, Wang Song, Yu Bing, Shen Youqing
Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266071, China.
Biomater Sci. 2021 Apr 7;9(7):2384-2412. doi: 10.1039/d0bm02013c. Epub 2021 Feb 12.
Photodynamic therapy is the most important treatment strategy in free radical therapy. However, tumor microenvironment hypoxia is a key obstacle in PDT. In order to overcome this obstacle, the strategy of in situ production of O/radicals by catalytic reaction in solid tumors was proposed. In recent years, it has been found that there are many oxygen-independent carbon-based free radicals that can generate toxic active free radicals under laser irradiation and lead to tumor cell death. Based on the rational design of multifunctional nano-medicine, the active free radical nano-generator has opened up a new way for the highly developed nanotechnology and tumor cooperative therapy to improve the therapeutic effect. In this paper, the research status of active free radical nano-generators, especially reactive oxygen species, including the construction mechanism of active free radical nanomaterials, is reviewed and the application of free radical nano-generators in tumor therapy is emphasized.
光动力疗法是自由基疗法中最重要的治疗策略。然而，肿瘤微环境缺氧是光动力疗法中的一个关键障碍。为了克服这一障碍，人们提出了通过实体瘤中的催化反应原位产生氧自由基的策略。近年来，人们发现有许多不依赖氧的碳基自由基，它们在激光照射下能产生有毒的活性自由基并导致肿瘤细胞死亡。基于多功能纳米药物的合理设计，活性自由基纳米发生器为高度发达的纳米技术与肿瘤协同治疗以提高治疗效果开辟了一条新途径。本文综述了活性自由基纳米发生器，尤其是活性氧的研究现状，包括活性自由基纳米材料的构建机制，并强调了自由基纳米发生器在肿瘤治疗中的应用。
