School of Chemistry and Chemical Engineering , Southwest University , Chongqing 400715 , P.R. China.
State Key Laboratory of Rare Earth Resource Utilization , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130021 , P.R. China.
ACS Nano. 2019 Nov 26;13(11):13144-13160. doi: 10.1021/acsnano.9b05985. Epub 2019 Oct 17.
Tumor cell metabolism and tumor blood vessel proliferation are distinct from normal cells. The resulting tumor microenvironment presents a characteristic of hypoxia, which greatly limits the generation of oxygen free radicals and affects the therapeutic effect of photodynamic therapy. Here, we developed an oxygen-independent free radical generated nanosystem (CuFeSe-AIPH@BSA) with dual-peak absorption in both near-infrared (NIR) regions and utilized it for imaging-guided synergistic treatment. The special absorption provides the nanosystem with high photothermal conversion efficiency and favorably matched photoactivity in both I and II NIR biological windows. Upon NIR light irradiation, the generated heat could prompt AIPH release and decompose to produce oxygen-independent free radicals for killing cancer cells effectively. The contrastive research results show that the enhanced therapeutic efficacy of NIR-II over NIR-I is principally due to its deeper tissue penetration and higher maximum permission exposure that benefits from a longer wavelength. Hyperthermia effect and the production of toxic free radicals upon NIR-II laser illumination are extremely effective in triggering apoptosis and death of cancer cells in the tumor hypoxia microenvironment. The high biocompatibility and excellent anticancer efficiency of CuFeSe-AIPH@BSA allow it to be an ideal oxygen-independent nanosystem for imaging-guided and NIR-II-mediated synergistic therapy systemic administration.
肿瘤细胞代谢和肿瘤血管增殖与正常细胞不同。由此产生的肿瘤微环境呈现出缺氧的特征，这极大地限制了氧自由基的产生，并影响光动力疗法的治疗效果。在这里，我们开发了一种具有双近红外（NIR）区域双吸收峰的缺氧依赖性自由基生成纳米系统（CuFeSe-AIPH@BSA），并利用其进行成像引导协同治疗。特殊的吸收为纳米系统提供了高光热转换效率，并在 I 和 II NIR 生物窗口中具有有利的匹配光活性。在近红外光照射下，产生的热量可以促使 AIPH 释放并分解，产生缺氧依赖性自由基，有效地杀死癌细胞。对比研究结果表明，NIR-II 比 NIR-I 的增强治疗效果主要归因于其更深的组织穿透和更高的最大允许暴露，这得益于更长的波长。NIR-II 激光照射下的热效应和有毒自由基的产生，在触发肿瘤缺氧微环境中癌细胞凋亡和死亡方面非常有效。CuFeSe-AIPH@BSA 的高生物相容性和优异的抗癌效率使其成为一种理想的用于成像引导和 NIR-II 介导协同治疗的缺氧独立性纳米系统，可通过全身给药实现。
