细胞骨架相互作用介导的线粒体动力学、定位和功能。
Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions.
机构信息
Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, India.
EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia.
出版信息
Cell Mol Life Sci. 2021 Apr;78(8):3969-3986. doi: 10.1007/s00018-021-03762-5. Epub 2021 Feb 12.
Abstract
The ability of a mitochondrion to undergo fission and fusion, and to be transported and localized within a cell are central not just to proper functioning of mitochondria, but also to that of the cell. The cytoskeletal filaments, namely microtubules, F-actin and intermediate filaments, have emerged as prime movers in these dynamic mitochondrial shape and position transitions. In this review, we explore the complex relationship between the cytoskeleton and the mitochondrion, by delving into: (i) how the cytoskeleton helps shape mitochondria via fission and fusion events, (ii) how the cytoskeleton facilitates the translocation and anchoring of mitochondria with the activity of motor proteins, and (iii) how these changes in form and position of mitochondria translate into functioning of the cell.
摘要
线粒体的分裂和融合能力，以及在细胞内的运输和定位，不仅对线粒体的正常功能至关重要，对细胞的正常功能也是如此。细胞骨架纤维，即微管、F-肌动蛋白和中间纤维，已成为这些动态线粒体形状和位置转换的主要动力。在这篇综述中，我们通过深入研究：（i）细胞骨架如何通过分裂和融合事件帮助塑造线粒体，（ii）细胞骨架如何通过马达蛋白的活性促进线粒体的易位和锚定，以及（iii）线粒体形态和位置的这些变化如何转化为细胞的功能，来探索细胞骨架和线粒体之间的复杂关系。
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