Department of Intensive Care Unit, General Hospital of Ningxia Medical University, Niangxia, China.
Eur Rev Med Pharmacol Sci. 2021 Jan;25(2):1087-1096. doi: 10.26355/eurrev_202101_24679.
Patients with Coronavirus Disease 2019 (COVID-19) suffer from anxiety, depression and sleep disorders due to isolation treatment, among other reasons. Whether non-drug interventions can be alternative therapies for COVID-19 patients with anxiety, depression and sleep disorders is controversial. Therefore, we conducted a meta-analysis and systematic review to evaluate the effects of non-drug interventions on anxiety, depression and sleep in patients with COVID-19 to provide guidance for clinical application.
We searched the following databases for randomized controlled trials (RCTs) from December 2019 to July 2020: China Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chongqing VIP Chinese Science and Technology Periodical Database (VIP), Wanfang, Cochrane Library, Web of Science, PubMed, MEDLINE and Embase. Two investigators independently screened the literature according to the inclusion and exclusion criteria, extracted data and evaluated the risk of bias in the included studies. Meta-analysis was performed using RevMan5.3 software.
A total of 5 articles with 768 subjects were included. Meta-analysis results indicated that non-drug interventions can reduce anxiety [SMD=-1.40, 95% CI (-1.62, -1.17), p<0.00001] and depression [SMD=-1.22, 95% CI (-2.01, -0.43), p=0.002] scores in patients with COVID-19. Descriptive analysis indicated that non-drug interventions can improve the sleep status of COVID-19 patients. Sensitivity analysis indicated that the meta-analysis results were stable. Egger's test and Begg's test showed no publication bias.
This meta-analysis found that non-drug interventions can reduce the anxiety and depression scores of patients with COVID-19. Due to the limitations of this study, more high-quality studies are needed to verify the findings, especially the effect of non-drug interventions on improving the sleep status of COVID-19 patients.
由于隔离治疗等原因，2019 年冠状病毒病（COVID-19）患者患有焦虑、抑郁和睡眠障碍。非药物干预是否可以作为 COVID-19 患者伴焦虑、抑郁和睡眠障碍的替代疗法存在争议。因此，我们进行了荟萃分析和系统评价，以评估非药物干预对 COVID-19 患者焦虑、抑郁和睡眠的影响，为临床应用提供指导。
我们检索了 2019 年 12 月至 2020 年 7 月的以下数据库中的随机对照试验（RCT）：中国生物医学文献数据库（CBM）、中国知网（CNKI）、重庆维普中文科技期刊数据库（VIP）、万方、Cochrane 图书馆、Web of Science、PubMed、MEDLINE 和 Embase。两名研究者根据纳入和排除标准独立筛选文献，提取数据并评估纳入研究的偏倚风险。使用 RevMan5.3 软件进行荟萃分析。
共纳入 5 篇文章，768 例患者。Meta 分析结果表明，非药物干预可降低 COVID-19 患者的焦虑[SMD=-1.40，95%CI（-1.62，-1.17），p<0.00001]和抑郁[SMD=-1.22，95%CI（-2.01，-0.43），p=0.002]评分。描述性分析表明，非药物干预可改善 COVID-19 患者的睡眠状况。敏感性分析表明，荟萃分析结果稳定。Egger 检验和 Begg 检验未显示发表偏倚。
本荟萃分析发现，非药物干预可降低 COVID-19 患者的焦虑和抑郁评分。由于本研究的局限性，需要更多高质量的研究来验证这些发现，特别是非药物干预对改善 COVID-19 患者睡眠状况的影响。
