人诱导多能干细胞衍生的外泌体作为治疗各种疾病的一种新策略。
Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases.
机构信息
Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, 5 Fu-hsing Street, Gueishan, Taoyuan 333, Taiwan.
出版信息
Int J Mol Sci. 2021 Feb 10;22(4):1769. doi: 10.3390/ijms22041769.
Abstract
Recently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for iPSCs to repair injured cells through the delivery of bioactive components. Animal reports of iPSC-derived exosomes on various disease models are increasing, such as in heart, limb, liver, skin, bone, eye and neurological disease and so forth. This review aims to summarize the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration.
摘要
最近，越来越多的研究表明诱导多能干细胞（iPSCs）及其衍生细胞具有治疗作用，主要通过旁分泌机制，除了它们的转分化能力。外泌体已成为 iPSCs 通过传递生物活性成分来修复受损细胞的重要旁分泌因子。关于 iPSC 衍生的外泌体在各种疾病模型中的动物报告越来越多，例如心脏、四肢、肝脏、皮肤、骨骼、眼睛和神经疾病等。本综述旨在总结 iPSC 衍生的外泌体在各种疾病模型中的治疗效果及其特性，如血管生成、细胞增殖和抗细胞凋亡，以期提高其在临床应用和功能恢复中的潜在作用。
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