Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland; Department of Mechanical & Manufacturing Engineering, Trinity College Dublin, University of Dublin, Ireland.
Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, Gliwice, Poland.
Mater Sci Eng C Mater Biol Appl. 2021 Feb;121:111857. doi: 10.1016/j.msec.2020.111857. Epub 2021 Jan 6.
Biodegradable strain sensors able to undergo controlled degradation following implantation have recently received significant interest as novel approaches to detect pathological tissue swelling or non-physiological stresses. In this study, the physicomechanical, electrochemical and active pressure sensing behavior of an electrically conductive and biodegradable poly(glycerol sebacate urethane) (PGSU) composite, reinforced with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) functionalized carbon nanotubes (CNTs), was evaluated in vitro. Analysis of these PGSU-CNTs composites demonstrated that the incorporation of functionalized CNTs into a biodegradable elastomer resulted in enhanced mechanical strength, conductivity and tailored matrix biodegradation. PGSU-CNT composites were subsequently formulated into flexible and active pressure sensors which demonstrated optimal sensitivity to applied 1% uniaxial tensile strains. Finally, cytocompatibility analysis a with primary neural culture confirmed that PGSU-CNT composites exhibited low cytotoxicity, and supported neuron adhesion, viability, and proliferation in vitro.
可生物降解的应变传感器在植入后能够进行受控降解，最近作为一种新的方法来检测病理性组织肿胀或非生理应激受到了极大的关注。在这项研究中，我们评估了一种导电且可生物降解的聚（甘油琥珀酸酯）聚氨酯（PGSU）复合材料的物理机械、电化学和主动压力传感性能，该复合材料中加入了聚（3,4-亚乙基二氧噻吩）聚苯乙烯磺酸盐（PEDOT：PSS）功能化碳纳米管（CNT）。对这些 PGSU-CNT 复合材料的分析表明，将功能化 CNT 掺入可生物降解弹性体中可提高机械强度、导电性和可控制备的基体降解性。随后，将 PGSU-CNT 复合材料制成柔性主动压力传感器，其对施加的 1%单轴拉伸应变表现出最佳的灵敏度。最后，与原代神经培养物的细胞相容性分析表明，PGSU-CNT 复合材料的细胞毒性较低，并支持体外神经元的黏附、存活和增殖。
