6至11个月非母乳喂养/混合喂养婴儿食用动物奶与婴儿配方奶粉的效果比较：一项系统评价（方案）

Effect of consumption of animal milk compared to infant formula for non-breastfed/mixed-fed infants 6-11 months of age: a systematic review (protocol).

作者信息

Imdad Aamer, Ehrlich Julie Melissa, Catania Joseph, Tanner-Smith Emily, Smith Abigail, Tsistinas Olivia, Bhutta Zulfiqar Ahmed

机构信息

Department of Pediatrics; Division of Pediatric Gastroenterology, Hepatology and Nutrition, SUNY Upstate Medical University, Syracuse, NY, USA

School of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.

出版信息

BMJ Open. 2021 Feb 12;11(2):e046370. doi: 10.1136/bmjopen-2020-046370.

DOI:10.1136/bmjopen-2020-046370

PMID:33579775

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7883848/

Abstract

INTRODUCTION

Prevalence rates of breastfeeding remain low even though the World Health Organization (WHO) and the American Academy of Pediatrics recommend exclusive breast feeding for the first 6 months of life in combination with appropriate complementary feeding beyond six 6 months of age. There have been several studies that address the implication of drinking animal milk and/or infant formula on children's health and development when breast feeding is not offered during the first year of life. Vast improvements have been made in infant formula design, which may increase its benefits compared with animal's milk. The objective of this review is therefore to synthesise the most recent evidence on the effects of the consumption of animal milk compared with infant formula in non-breastfed or mixed breastfed infants aged 6-11 months.

METHODS AND ANALYSIS

We will conduct a systematic review and meta-analysis of studies that assessed the effect of animal milk compared with formula or mixed-fed (breastmilk and formula) on infants aged 6-11 months. The primary outcomes of interest include anaemia, gastrointestinal blood loss, weight for age, height for age and weight for height. We will include randomised and non-randomised studies with a control group. We will use the Cochrane risk of bias tools to assess the risk of bias. We will use meta-analysis to pool findings if the identified studies are conceptually homogenous and data are available from more than one study. We will assess the overall quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach.

ETHICS AND DISSEMINATION

This is a systematic review, so no patients will be directly involved in the design or development of this study. The findings from this systematic review will be disseminated to relevant patient populations and caregivers and will guide the WHO's recommendations on formula consumption versus animal milk in infants aged 6-11 months.

TRIAL REGISTRATION NUMBER

CRD42020210925.

摘要

引言

尽管世界卫生组织（WHO）和美国儿科学会建议在生命的前6个月进行纯母乳喂养，并在6个月龄之后配合适当的辅食喂养，但母乳喂养的普及率仍然很低。有多项研究探讨了在生命的第一年不进行母乳喂养时，饮用动物奶和/或婴儿配方奶粉对儿童健康和发育的影响。婴儿配方奶粉的设计有了很大改进，与动物奶相比，其益处可能有所增加。因此，本综述的目的是综合关于6至11个月非母乳喂养或混合喂养婴儿饮用动物奶与婴儿配方奶粉效果的最新证据。

方法与分析

我们将对评估动物奶与配方奶粉或混合喂养（母乳和配方奶粉）对6至11个月婴儿影响的研究进行系统综述和荟萃分析。主要关注的结果包括贫血、胃肠道失血、年龄别体重、年龄别身高和身高别体重。我们将纳入有对照组的随机和非随机研究。我们将使用Cochrane偏倚风险工具评估偏倚风险。如果所纳入的研究在概念上具有同质性且有多个研究的数据可用，我们将使用荟萃分析汇总研究结果。我们将使用推荐分级评估、制定和评价方法评估证据的总体质量。