老年人全血浆同型半胱氨酸与抑郁症状的关系。
Total Plasma Homocysteine and Depressive Symptoms in Older Hispanics.
机构信息
Laboratory of Neuroscience, Institute for Biological Research, University of Zulia, Maracaibo, Venezuela.
Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, KU University of Leuven, Leuven, Belgium.
出版信息
J Alzheimers Dis. 2021;82(s1):S263-S269. doi: 10.3233/JAD-201062.
BACKGROUND
Very few studies have investigated the association between total plasma homocysteine (tHcy) and depressive symptoms in older Hispanics.
OBJECTIVE
To test the hypothesis that high tHcy associates with depressive symptoms in older Hispanics.
METHODS
A total of 1,418 participants .55 years old from the Maracaibo Aging Study (MAS) underwent standardized neurological, neuropsychiatric, and cardiovascular assessments. The Neuropsychiatric Inventory Depression Subscale (NPId) was used to assess the burden of depressive symptoms. The tHcy levels and other biochemical parameters in blood samples were measured. Univariate and multivariate logistic regression models were applied.
RESULTS
Participants with depressive symptoms had higher levels of tHcy than those without (15.1 versus 13.9 µmol/L; p = 0.009). Elevated tHcy levels were associated with depressive symptoms after adjusting for age, sex, education, smoking, diabetes, hypertension, alcohol intake, stroke, and dementia (OR = 1.58; 95% CI, 1.18-2.12).
CONCLUSION
Elevated levels of tHcy were associated with depressive symptoms in older Hispanics living under the nutritional and environmental conditions of a developing country.
背景
很少有研究调查全血浆同型半胱氨酸（tHcy）与老年西班牙裔人群抑郁症状之间的关系。
目的
检验高 tHcy 与老年西班牙裔人群抑郁症状相关的假设。
方法
共有 1418 名年龄在 55 岁及以上的马拉开波老龄化研究（MAS）参与者接受了标准化的神经、神经精神病和心血管评估。使用神经精神病学损伤抑郁量表（NPId）评估抑郁症状的负担。测量血液样本中的 tHcy 水平和其他生化参数。应用单变量和多变量逻辑回归模型。
结果
有抑郁症状的参与者的 tHcy 水平高于无抑郁症状的参与者（15.1 比 13.9 µmol/L；p = 0.009）。在调整年龄、性别、教育、吸烟、糖尿病、高血压、饮酒、中风和痴呆后，高 tHcy 水平与抑郁症状相关（OR = 1.58；95%CI，1.18-2.12）。
结论
在发展中国家的营养和环境条件下生活的老年西班牙裔人群中，tHcy 水平升高与抑郁症状相关。
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